Research On Manufacturing Method And Performance Of PLGA/PCL Composite Artificial Bone Scaffold At High Temperature Extrusion 3D Printing

Human bone tissue has the ability to self-repair,but severe bone defects caused by trauma or tumors are difficult to repair by the human body.In clinical practice,autologous or allograft methods are generally used for treatment.Artificial bone scaffolds mainly use natural or synthetic polymers as raw materials,which can replace traditional orthopedic implants to be implanted into bone tissue defect sites to achieve repair of defective bone tissue.In this paper,PLGA and PCL are used as matrix materials,?-TCP is used as an auxiliary material,and a composite artificial bone scaffold is prepared by high-temperature extrusion3 D printing.Study the printing process of the stent,test and analyze the mechanical properties,degradation performance and biological properties of the stent,and optimize the preparation process based on the performance of the stent.The main research contents of this paper are as follows:(1)Research on the process and process of high temperature extrusion printing of the stent.The general process of high-temperature extrusion printing of the stent was established,and a high-temperature extrusion printing platform was set up.Taking the PLGA / ?-TCP composite scaffold as an example,the high temperature extrusion printability of the scaffold was studied,and the approximate printing process parameter range was established.Twelve types of stents were designed for printing experiments.The macro geometry of the printed stents was used as the goal,and the best printing process parameters for various stents were established.(2)Preparation and performance of PLGA / ?-TCP artificial bone scaffold.Nine groups of PLGA / ?-TCP scaffolds with different material ratios,different stent layer heights,different hole types and apertures were printed using the best printing process parameters.Investigate the properties of the printed scaffold,including its geometry,mechanical properties and cell proliferation performance.The orthogonal design method was used to determine the optimal scaffold design method.The experiments showed that the compressive strength of the scaffold was 6.23 MPa,the Young's modulus was 234.925 MPa,and the OD value(day5)was 1.176.Multiplication performance.(3)Preparation of PLGA / PCL / ?-TCP composite scaffold and study of its performance.A PLGA / PCL / ?-TCP composite scaffold and three control scaffolds(pure PCL scaffold,pure PLGA scaffold,and PCL / PLGA scaffold,respectively)were designed.Different printing methods of different material combination brackets were established.For the PLGA /PCL / ?-TCP composite scaffold,a dissolution-lyophilization-melt extrusion printing method was used.Perform a performance study of the printed stand.The results of the stent performance research show that the PCL / PLGA / ?-TCP composite stent has the best comprehensive performance,its microscopic surface morphology is better than other stent,its compressive strength is 8.2MPa,and its Young's modulus is 236.02 MPa,which is significantly better.For other scaffolds,the mechanical properties of cancellous bone can be basically met.