The Synthesis And Application Of Carbon Dots-BODIPY Covalent Organic Framework Nanomaterials

As an emerging crystalline porous material,covalent organic frameworks(COFs)have attracted great interest due to their adjustable porosity and tunable skeletal structures.The application of COFs depends on the chemical function of the building units or the postmodification of the frameworks.COFs have attracted widespread attention in various applications.However,since most of COFs have the disadvantages of large size,low water dispersibility and poor cell permeability,the development of COFs with biomedical functions is still a huge challenge.Carbon dots(CDs)have been proved to be the building blocks of framework materials due to their ultra-small size and abundant functional groups.In this work,we constructed COFs by using CDs as a carrier,and studied its application in cancer treatment.The major content is as follows:(1)In this work,diamine molecules p-phenylenediamine and BODIPY were selected as model monomers to react with aldehyde-containing CDs and construct nanoscale COFs,named CCOF-1 and CCOF-2,respectively After modified with poly(ethylene glycol)(PEG),the formed CCOF-1@PEG and CCOF-2@PEG are stable and well-dispersible in aqueous media.(2)CCOF-2@PEG exhibited strong ROS-producing ability.Cellular experiments showed that CCOF-2@PEG could be endocytosed by tumor cells and showed good biocompatibility.Moreover,CCOF-2@PEG could also effectively produce ROS in cells under light conditions to kill tumor cells.In vivo experiments further verified that CCOF-2@PEG had excellent anti-tumor effect and good biosafety in vivo.This work demonstrates a new strategy for manufacturing COFs-based functional platforms for biomedical applications.