Synthesis And Application Of Chiral M₂L₃-type Metal-organic Coordination Cage

Metal-organic coordination cages dominated by non-covalent bonds often have dynamic reversibility,poor stability,but are characteristic of orderly structure and specific functions.Based on the coordination bond-oriented self-assembly,this thesis designed and synthesized the supramolecular metal-organic cages with triangular bipyramid structure,and further explored its application in molecular recognition and separation.Chapter 1 briefly introduced the development of supramolecular chemistry,as well as theoretical basis,research progress and applications in various fields of self-assembly systems oriented by coordination bonds.Chapter 2 chapter,three chiral binaphtylbipiridine ligands L1-L3 first were prepared.Then,using the one-pot method,the resulting ligands were coordinated to ferrous ions to afford three Fe₂L₃-type metal organic coordination cages,Cage 1-3,with a trigonal bipyramidal structure,respectively.The coordination cages were fully characterized by elemental analyses,IR,NMR,MS,UV-vis,circular dichroism spectrum and transmission electron microscopy techniques.Chapter 3 explored the potential application of these metal-organic coordination cages.The results showed that Cage 1 exhibited the special ability in molecular recognition and separation.NMR measurements showed that Cage 1 can selectively respond to lysine,but not to other nineteen natural amino acids.MS data also indicated that Cage 1 can combine with one or several lysine molecules.The DOSY 2D NMR experiments of the mixed solution of Cage 1 and lysine confirmed that both them had similar diffusion coefficients.Moreover,Cage1 as powder can selectively absorb the lysine in the mixed amino acid aqueous solution.Chapter 4 introduced all the experimental methods,as well as the specifications of experimental drugs and the specifications of test instruments.