Study On The Chiral Separation And Fluorescence Sensing Performance Of Coordination Porous Crystalline Materials

Coordination porous crystalline materials is made by connecting inorganic and organic units through strong bonds.It can flexibly change its components to change its geometry,size and function.By combining metal-containing units(SBU)with organic linkers and use strong bonds(network synthesis)to create an open crystal framework with permanent porosity.It is new and immature in the field of materials,but it has a high surface area,structural diversity and customizability,which has aroused wide interest and demonstrated various applications,such as gas adsorption and separation,high-efficiency catalysis,and cleaning energy,chiral splitting,luminescence sensing and many other fields.In terms of chiral resolution,coordination porous crystalline materials with a chiral structure can provide a unique chiral environment,showing great application prospects in asymmetric synthesis and chiral separation,but chiral coordination porous crystalline materials exists factors such as difficulty in synthesis and high cost,it have severely restricted their development.The specific reason is the introduction of a single chiral source.Many single chiral sources are very expensive.Another reason is that the introduction of chiral sources is difficult to synthesize due to the overall flexibility of the ligand and difficult to apply on a large scale.In terms of luminescence sensing,many varieties of fluorescent probes based on small organic molecules have been developed,but they have a unified shortcoming,that is,small organic molecules are difficult to recycle after using,resulting in waste of resources and high prices.In this paper,following the function-oriented goal,firstly,because chiral amino acids are widely found in nature,they are diverse and inexpensive,and the amino acid skeleton contains two groups that are easy to modify and functionalize amino and carboxyl groups.The introduction of the chiral source into the coordination cage framework will help the structure preparation and functional research of chiral metal-organic framework materials.We chose Lphenylalanine as the single chiral source and designed and synthesized a three Dentate flexible ligand,and use the ligands and lanthanide metal to synthesize two chiral coordination cages,and explore the structural differences and structure-oriented of these two coordination cages.After the difference in properties,the coordination cage 1 was used as the best chiral adsorbent to study its enantioselective adsorption of racemic diols,amines and quinazolinones.The preferences for different substrate adsorption configurations are different,and the coordination cage 1 is used as the stationary phase of the chromatographic column,the HPLC chiral column is prepared,and it is found that it can achieve baseline separation of a variety of compounds,and has good selectivity and chromatographic resolution.Then,using the urea group as the functional site,a twodimensional functional material(complex 3)was designed and synthesized,which was used as a new fluorescent sensor for the detection of picric acid,which showed high sensitivity,good selectivity and rapidity characteristics of luminescence quenching response,and it can be regenerated simply and quickly,with excellent recyclability.The work of this paper mainly provides a feasible idea for the design of function-oriented coordination porous crystalline materials.