Preparation And Properties Of Nanofibers With "Core-Shell" Structure Loaded With Traditional Chinese Medicine

In this study,the electrospinning technology was used to load the puerarin and the compound traditional Chinese medicine alumbing system into the core scaffold of the fiber,and the fiber performance was verified by experimental means,and the prepared fiber can be effective Enlarging the area of action of the medicine makes the distribution of the medicine more even,providing a new idea for the use and development of Chinese medicine.The main research contents of this paper are as follows:(1)L-polylactic acid(PLLA)and gelatin(Gel)were selected as the main carriers of puerarin,and multi-walled carbon nanotubes(MWNTs)pretreated with strong acid were used as reinforcement materials,and PLLA/Gel/MWNTs were prepared by electrospinning technology.Blood vessel stent structure.Characterize and analyze the surface morphology,functional group distribution,hydrophilicity,degradability and mechanical tensile properties of the fiber membrane,and finally determine the amount of each raw material added,so that the performance of the fiber membrane matches the natural blood vessel,and it is Pueraria lobata root.The loading of the element provides a suitable carrier.(2)Puerarin was selected as the loading object,and PLLA/Gel/MWNTs-PUE fibers were prepared by coaxial electrospinning technology.The fiber performance changes were tested by SEM,TEM,FT-IR,OCA,and mechanical tensile tests,and the drug release test in vitro Confirm the release rate of the drug in the fiber,and finally select the cell compatibility and blood compatibility as the verification of the fiber's good biocompatibility.The mechanical properties and hydrophilicity of the PLLA/Gel/MWNTs-PUE fibers prepared in the research can match the requirements of natural blood vessels,and the puerarin is slowly released as the carrier gradually degrades,achieving the purpose of long-term high efficiency.The materials used will not cause damage to cells and support cell adhesion and growth.(3)Polyvinylpyrrolidone(PVP)is selected as the drug carrier,and borneol and alum are respectively loaded on the core and shell parts of the fiber using coaxial electrospinning technology.The smooth loading of the drug is determined by morphology observation and functional group analysis.The thermal decomposition behavior judges the distribution mode of the drug.Finally,the dissolution effect of the borneol in the fiber is characterized by GC-MS.It is found that the "core-shell" structure alum ice fiber prepared by this method can effectively improve the dissolution efficiency of the borneol,and the dissolution efficiency of the borneol can be effectively improved at 240 min.The dissolution rate has reached 82%.