Porous Aromatic Framework Supported-gold Catalyzed The Hydration Of Alkynes And Supported-ruthenium Catalyzed Redox Isomerization Of Allylic Alcohols

Ketone compounds are important agricultural chemicals,pharmaceuticals and fine chemicals.Among them,as a pharmaceutical intermediate,it exhibits good pharmacological activities such as anti-inflammatory,antibacterial,anti-tumor,hypolipidemic,and antitussive.The traditional synthesis method is prepared by reacting benzaldehyde with halogenated hydrocarbons.However,a large number of oxidants,reducing agents,organometallic reagents,etc.are used in the process of the reaction,and a large number of toxic and harmful by-products are produced,which will cause damage to the environment.With the continuous development of green chemistry,it has become an important task in the field of organic chemistry to develop and design a green,environmentally friendly and recyclable catalytic reaction system to synthesize ketone compounds.We successfully synthesized a high specific surface area and good stability of organic aromatic frameworks(PAFs)materials,and confirmed its structural properties through a series of characterization methods.Due to the efficient catalytic effect and high selectivity of transition metals and their complexes,ketone compounds are synthesized by complexing transition metal gold and ruthenium complexes as catalysts.The main content of this paper is divided into two parts: The first part is the use of Au@PAFs catalyst under neutral conditions without acid,alkali and additives.It can well catalyze the conversion of alkynes to ketones in methanol and water solvents.A series of substrates with different groups have good tolerance;the reaction is environmentally friendly,high catalytic efficiency,and no waste is generated during the reaction.The second part is the use of Ru@PAFs catalyst to catalyze the intramolecular hydrogen transfer of enol to synthesize saturated ketones under weak alkaline conditions to obtain a series of high-yield products;the reaction atom utilization rate is high,and the synthesis steps are simple and easy to operate.Both of these reactions are of high atom economy and are synthesized in one step;what is more noteworthy is that the catalyst used can be recycled through simple filtration;this is fully in line with the concept of sustainable development.