Preparation And Application Of Sensors Based On Europium-based Infinite Coordination Polymers

Infinite coordinate polymers(ICPs)have some advantages,such as better dispersity,more chemically functionalized open sites,and could automatically assemble into micro-or nano-particles with low crystallinity.Moreover,they also have no specific crystal shape and can adjust the size and shape of particles flexibly compared with other coordination polymers.In recent years,such nanomaterials have attracted the attention of researchers and thus are widely used in many fields,such as sensing probes,luminescent devices,and biological imaging.In this thesis,based on ICPs synthesized by rare earth metal element Europium and adenosine monophosphates(Eu-AMP),combined with other quantum dot nanomaterials,three biosensoes with excellent performance were parepared and further applied to the detection of the targets and real samples.The main contents are as follows:1.The concepts,synthesis methods and applications of ICPs are briefly described.Furthermore,the main contents and significance of this thesis was pointed out.2.Bisphenol A(BPA)is one of the endocrine disruptors,which could cause precocious puberty and other reproductive behavior and growth problems in infants.In this chapter,a ratiometric fluorescent sensor was constructed based on carbon dots(CDs)encapsulated in Eu-AMP,and based on it,a portable visualization coffee ring was designed for the detection of BPA in aqueous environment.The results showed that the fluorescence intensity ratio showed a good linear relationship with BPA concentration in the range of 0.1?100?M,and the limit of detection(LOD)was 20 n M(S/N=3).The change of CDs@Eu-AMP fluorescence color with the addition of different concentrations of BPA could be easily observed by the naked eye under the irradiation of310 nm UV lamp,and the change of color and the sizes of the produced coffee rings could be observed to quickly and visually detect the actual samples.3.As a commonly used antibiotic,tetracycline hydrochloride could interfere with bacterial protein synthesis,inhibit bacterial activity,and is widely used in the treatment of human and animal husbandry diseases.It could cause allergic reactions in sensitive individuals by entering the human body through the food chain,and long-term use of it could lead to drug resistance.Therefore,the quantitative analysis of tetracycline hydrochloride is of particular importance.In this chapter,an electrochemiluminescent(ECL)sensor based on titanium carbide metal quantum dots(MQDs)combined with Eu-AMP was developed and applied to detect tetracycline hydrochloride in the water environment.The obtained results showed that the ECL of the MQDs/Eu-AMP material produced fluorescence quenching along with the increase of concentration.A good linearity was observed in the range of 0.1?100?M,with a linearity of?I=828.0c+103.6(R~2=0.992)and LOD of 18 n M(S/N=3).In addition,the MQDs/Eu-AMP sensor gave satisfactory results for the detection of tetracycline hydrochloride in real samples.4.Hydrogen peroxide(H₂O₂)has been widely used in the field of pharmaceutical,civil and industrial applications.Excessive exposure to H₂O₂could lead to various pathologies and even the risk of cancer.Therefore,the detection of H₂O₂ content is crucial.In this chapter,an electrochemical sensor with the electrochemical response for H₂O₂ detection was established by wrapping prussian blue nanocubes(PBNCs)with Eu-AMP.The sensor showed good linearity in the concentration range of 2?100?M and 100?400?M with LOD of 0.2?M(S/N=3).The sensor was used for the detection of H₂O₂ in real serum sample with acceptable results.