Aerobic Oxidative Hydroxysulfurization Of Gem-difluoroalkenes Towards α,α-difluoro-β-hydroxysulfides

Organofluorine compounds have been applied more and more extensively in the field of pharmaceutical chemistry,agrochemistry and materials sciences.Particularly,the difunctionalization of gem-difluoroalkenes acts as a powerful tool to broaden the diversity of organofluorine compounds significantly,and draws widespread attention.It should also be noted that gem-difluoroalkenes,tri-or tetra-substituted,possess slightly greater steric hindrance and more complex charge distribution in comparison with terminal alkene,which might result in a rather low yield and selectivity in the corresponding bifunctionalization mode.Considering the limitations of bifunctionalization modes,the development of novel and efficient difunctionalization of gem-difluoroalkenes in a greener manner is still highly desirable.An efficient aerobic oxidative hydroxysulfurization of gem-difluoroalkenes with aryl or even alkyl thiols towards α,α-difluoro-β-hydroxysulfides has been presented.The reaction is greatly appreciated by its high chemo-and regioselectivity,moderate to excellent yields,broad substrate scope,as well as larger scales in the absence of any transition-metals or phosphine reductants,which conforms to the ideology of green chemistry including high efficiency,easy operation and environmental safety.