Synthesis Of Cyclic Nitrones And Their Preliminary In Vitro Antitumor Activity

Nitrones were found to exhibit attractive biological values as immuno spin trapping agents.However,successful clinical cases of nitrone therapeutics are still lacking,although these compounds showed very high safety profiles.Herein we report the synthesis and antiproliferative activity of a series of structurally diverse nitrone derivatives against a panel of 5 cancer cell lines,based on which indole-and pyrrole-fused were further evaluated by analogue preparation and in-vitro screening.Analogues with moderate to good potency were identified.This study shows the basics for further pursuit of nitrone-type small molecules in chemotherapy.