Synthesis And Application Of Novel Fluorescent Probes For Detecting Chiral Drugs Of Prazol

So far,Since the release of Omeprazole,the first proton pump inhibitor to effectively treat gastrointestinal disorders,The research and development of such drugs has never stopped.With the development of society and the change of people’s dietary structure,the incidence and types of gastrointestinal diseases have increased significantly,and the demand for proton pump inhibitors has also increased year by year.The rapid development of society is also accompanied by the aggravation of environmental pollution problems.In particular,heavy metals are extremely harmful to nature and living organisms,and serious illnesses are life threatening.Fluorescent probes are very popular as a method that can detect ions,small molecules and biomolecules simply,conveniently and quickly.It will be of great significance if they can detect and identify proton pump inhibitor drugs,chiral molecules and cations.In this paper,seven fluorescent probes W1-W7 were synthesized using BINOL as the backbone;two fluorescent probes W8-W9 were synthesized using BINAM as the backbone,and their recognition performance was tested.This article is divided into four chapters:The first chapter introduces the composition,parameters and mechanism of fluorescent probes,briefly describes and exemplifies the four major applications of fluorescent probes,and briefly describes the five major prazole drugs on the market and their pharmacological characteristics.In Chapter 2,the W1 probe was synthesized using S-BINOL as the backbone.It can identify all the prazole drugs currently owned by the research group in methanol solution,and the ability to recognize esomeprazole magnesium salt is the best;Recognize chiral molecules;it can effectively recognize Ag⁺and Hg²⁺,and can distinguish Ag⁺and Hg²⁺by adding cysteine.The W2 probe was synthesized with R-BINOL as the backbone,and its ability to recognize the above three types of substances in methanol solution is basically the same as that of the W1 probe.In Chapter 3,five probes of W3-W7 were synthesized using S-BINOL as the backbone.In methanol solution,these five probes can identify all the prazol drugs currently owned by the research group,and they also have the best ability to identify esomeprazole magnesium salt.Among them,W3,W5 and W7 probes can effectively identify and distinguish S-di-tert-butylsulfinate thioester and R-di-tert-butylsulfinate thioester in the recognition of chiral molecules,while W4 and The W6 probe has no ability to recognize chiral molecules.For cation recognition,the W4 and W6 probes have the ability to recognize Fe³⁺,Ag⁺and Hg²⁺and Fe³⁺<Ag⁺<Hg²⁺,while the W3,W5 and W7 probes have basically the same recognition capacity for Fe³⁺as the former two,but for Ag⁺and The recognition ability of Hg²⁺is weakened.In Chapter 4,the W8 probe was synthesized with S-BINAM as the backbone.It can identify all the prazole drugs currently owned by the research group in an aqueous solution.Among them,the ability to recognize fenbendazole is the worst,and it has the worst ability to recognize esomeira.Magnesium azole has the best recognition ability;In the recognition of chiral molecules,it can effectively recognize S-phenethylamine and R-phenethylamine;it can also recognize lysine and arginine in amino acids.The W9 probe was synthesized with R-BINAM as the backbone.It changes the fluorescence of the lansoprazole precursor in the prazole drugs in the aqueous solution,and it no longer quenches the fluorescence like other prazole drugs,but There is a slight upward trend;S-phenethylamine and R-phenethylamine can also be effectively identified in the recognition of chiral molecules.