Construction Of Stable Ni@Ni_xN@C Nanocomposites Upon A Dual-ligand-MOF Manipulating Strategy For The Synthesis Of Aniline Drug Intermediates

The catalytic reaction of the conversion of aromatic nitro compounds into aniline compounds was widely used in the field of drug synthesis and had received much attention.At the present stage,the realization of this type of conversion usually relied on transition metal catalysts.,among of which nickel-based catalysts was extensively used due to their lower price and better activity.However,there still existed some insurmountable problems such as weak selectivity and poor stability..In view of above issues,the following research had been carried out:(1)A new organic framework compound with two ligands was developed in this thesis,and used as a precursor to prepare a stable Ni-based nanocomposite catalyst through high-temperature pyrolysis.By means of XRD,TEM and XPS,the structure of the catalyst was confirmed to be coated with carbon film,with nickel nitride dispersed on the surface of nickel nanoparticles.It was a kind of Ni@Ni_x N@C composite material with adjustable surface composition and stable structure.The size of Ni nanoparticles was about 10-20 nm.In addition,the material was magnetic,easy to recycle and multiple recycling.(2)The Ni@Ni_xN@C composite catalyst was applied in the synthesis of aniline compounds.According to optimizing the reaction condition,aniline compounds was finally synthesized under milder conditions,with yield reaching 100%.At the meanwhile,the stability and recycling of the catalyst in the reaction were investigated.(3)During this research,it was found that Ni@Ni_x N@C composite material could be used as a photocatalyst to convert nitrobenzene into aniline under visible light irradiation.According to regulating various reaction conditions,the final yield of aniline reached 92% after 5 h visible light under room temperature.This synthetic method is more environmentally friendly.The research in this paper found that the Ni@Ni_x N@C composite material derived from MOF can be well used in the synthesis of aniline drug intermediates.The synthesis method is green and environmentally friendly and meets the current production needs.