| Biopharmaceutics classification system II drugs（BCSⅡ）has low solubility but high permeability,dissolution is the speed limit step for drug absorption.To improve the solubility of oral preparations,it is crucial to develop a carrier material that significantly improves drug solubility.metal-organic framework（MOF）derived oxide materials have attracted attention for the advantages of property stability,large specific surface area,uniform morphology,and biodegradable.When loading insoluble drugs,the pore domain restriction effect can change the drug crystallization state and reduce the drug particle size,thus improving the solubility.Structural control has always been one of the most effective strategies in material design and preparation.The size,shape,and spatial structure,etc.,of nanomaterials always play a key role in drug transportation and storage performance.Among the various morphologies,the hollow bowl-shaped morphology has its unique advantages,such as the hemispherical hollow hole structure,low symmetry and high packing density,etc.For drug delivery,the bowl-like opening shape and its internal cavity can significantly enhance the loading of drugs and have a certain controlled release function.With the continuous development of nanocatalytic medicine,the relationship between catalysis and medicine has become closer.In this study,while preparing MOF-derived oxides for drug carrier research,we also expanded the study of the electrocatalytic applications of transition metal selenides and sulfides.The specific contents are as follows:1 Used the single metal Co-MOF as the precursor and adjusted the calcination temperature to obtain Co-MOF-x（x is the calcination temperature）.Firstly,we screened out Co O with a bowl-shaped morphology,large specific surface area and pore structure as a drug carrier,and carried out the drug-loaded composite material（Co O-CBZ）XRD,IR,DSC characterization to prove the successful loading of CBZ.Next,we have systematically investigated the dissolution and the stability of Co O-CBZ at different p H.Finally,we tested the cytotoxicity and the results showed that the appropriate concentration range of Co O-CBZ should be less than 100μM,which indicates that Co O has the potential as a drug-carrying material.2 A unique hollow bowl-shaped NiCo-MOF precursor was prepared,and the Ni O·Co O with regular morphology and uniform particle size was obtained after low-temperature calcination.Its specific surface area and mesoporous structure were significantly better than Co O.Subsequently,we screened the optimal drug carrier through XRD,TEM,SEM,and other characterizations,and carried out the drug loading test of CBZ.Similarly,we also carried out the dissolution,drug loading,stability,and cytotoxicity measurements of the Ni O·Co O-CBZ,and the results were significantly improved compared to Co O-CBZ.3 NiCo2Se4/NiCoS4 heterostructure catalyst was prepared.Due to the heterostructure interfaces can facilitate electron transfer,enhance the electrolyte diffusion and improve the catalytic synergistic effect,it is beneficial to improve the electrocatalytic performance of NiCo2Se4/NiCoS4.When the current density is 10 m A cm-2,the overpotentials of oxygen evolution reaction（OER）and hydrogen evolution reaction（HER）are 248 m V and 180 m V,respectively,and the voltage of overall water splitting（OWS）reaction is 1.660 V.In the application of zinc-air batteries（ZABs）,the charge-discharge voltage gap is 0.98 V(50 m A cm-2)and the specific capacity is693.17 m A h g-1.This research can offer a new avenue to design and prepare abundant-element-based cost effective,efficient and durable electrocatalysts with multifunctionalities that hold great promises to be applied in electrochemical devices. |
