Preparation Of Multi-shell Mesoporous Organic Silica Nanospheres And Its Application In Drug Delivery

As a member of the new type of nanomaterials,mesoporous organsilica nanoparticles(MONs)have a distinct mesoporous structure,huge surface area,easy-to-functionalized surface and a skeleton that is convenient for doping with various organic groups.Compared with inorganic mesoporous silica nanoparticles,the MONs have better structural stability and biocompatibility due to the presence of organic groups in the framework,which makes them have great potentials in the field of biomedicine,such as stimulated drug release and targeted drug delivery.By adjusting its structure and morphology,the applications of MONs can be enriched.In this paper,simple and easy-to-operate synthesis methods are used to synthesize MONs with innovative morphology and structure,and the study of their biological properties,include the following two parts:(1)Deformable double-shelled hollow mesoporous organosilica nanocapsules(DDHMONs)were successfully prepared by the multi-interface etching method.This unique flexible double-shelled structure of DDHMONs a highly even outer shell diameter(320 nm)and inner shell diameter(180 nm)with fine dispersibility in water.In addition,the synthesized DDHMONs also have large surface area(1233 m~2/g),uniform mesopores(2.21 nm),and large pore volume(1.63 cm~3/g).More importantly,the DDHMONs have good biocompatibility and can effectively load the anticancer drug doxorubicin(DOX)(335μg/mg).The results prove that the DDHMONs can deliver DOX to cells more efficiently,thus showing great potential.(2)The benzene-bridged mesoporous organosilica nanospheres are etched into a kind of MONs with double pore diameters through hydrothermal reaction.This method can easily obtain double pore MONs with large pores in the outer shell and small pores in the inner shell.In addition,this double pore MONs also has a large surface area(877 m~2/g)and a large pore volume(0.99cm~3/g).Moreover,the loading capacity of this type of double pore MONs for DOX reached 0.355 mg/g,and related data also showed that the double pore MONs loaded with DOX had a higher cell killing efficiency(About70%of the cells were killed),showing a good chemotherapy efficacy.