Structure Control And Biomedical Properties Of Mesoporous Organic Silica Nanoparticles

Periodic mesoporous organosilica nanoparticles(PMO)not only have high specific surface area,big pore volume,uniform pores and other characteristics belong to mesoporous materials,but all kinds of organic groups can dope into its framework.So,we can design the function according to needs,which makes the PMO material more intelligent.In addition,comparing with the traditional inorganic mesoporous silica,mesoporous organosilica nanoparticles have good biocompatibility,higher stability in vivo and is playing a more and more important role in the biomedical field.By controlling the pore size or the structure of PMO materials,they can be used for delivery biomacromolecule such as gene,protein and so on.This paper mainly explores variety of new methods to prepare new types of PMO nanoparticles.The contents mainly make up of the following three parts:1.We prepared ethane-bridging PMO with large pores for the first time in a water-ethanol/n-hexane biphasic reaction system.Those NPs possess radially oriented pores,high surface area,tunable particle size and good biocompatibility,which endow the PMO NPs excellent loading capacity for bio-macromolecule such as protein and RNA.Besides,the effect of the reaction parameters including temperature and stirring rate on the pore size are systemically investigated and the formation mechanism of the large pores is discussed,which will provide new idea for preparation of large mesoporous nanoparticles.2.We report a biphasic-to-monophasic successive co-assembly approach to synthesize yolk-shell structured mesoporous organosilica nanoparticles(PMO),this method intrinsically simple and requires neither sacrificial templates nor multistep coating processes.The shell thickness of the yolk-shell PMO NPs can be tuned between 23-53 nm.The chemotherapy drug doxorubicin(DOX)is loaded into the yolk-shell PMO to kill human breast cancer cells,showing a higher chemotherapeutic efficacy.3.We report a simple method to synthesis mesoporous platinum(MP)with the help of the KBr,then the periodic mesoporous organsosilica will eccentric package on the surface of the MP via a anisotropic growth approach to get the PMO-based nanocomposite with Janus structure(JPMO@MP).The JPMO@MP nanoparticles possess good dispersion and uniform size with a mean diameter of 152 nm.The PMO shell anisotropic growth on a side of the mesoporous platinum have available radially oriented pores.This nanocomposite structure with independent multistage pore structure provides a new possibility for its application in nanomedicine.