The Study Of Determination Of Chlorinated Propanols Contaminants Released From Food Contact Papers And Their Health Risk Assessment

The Gas chromatography–mass spectrometry method(GC-MS)was established to detect the migration and water extract of four types of chlorinated propanols in food contact papers.The solutions obtained by the experiment were purified by a diatomaceous earth column,and derivatized with heptafluorobutyrylimidazole,followed by analysis using GC-MS,and quantified by internal standard method.For migration experiment,the linear range of the four target compounds is 0.02～0.2 mg/L,the limit of detection(LOD)and the limit of quantification(LOQ)were 2.0 mg/kg and 6.0 mg/kg,respectively.The recovery rate of spiked sample is 87.3%～109%,and the relative standard deviation is 1.1%～9.5%.For water extraction,the linear range of the four target compounds is 0.02～0.2 mg/L,the LOD and LOQ were 2.0 μg/L and 6 μg/L,respectively.The methods have excellent recovery rate and good precision,which is satisfied for the analysis of chlorinated propanols at μg/kg level.The investigation of release behavior of chlorinated propanols from food contact papers revealed that the water extraction method is more severe than the migration method.In case of migration method,the aqueous-based simulants are more severe than the fatty simulants.In case of water extraction method,cold water treatment is more severe than hot water treatment.In the range of 10°C～60°C,the extraction time has a greater influence on the extraction efficiency of chlorinated propanols than the extraction temperature.However,when the extraction temperature was increased to 60°C～90°C,the level of chlorinated propanols in water extract would gradually decrease due to the volatilization loss caused by high temperature.The risk assessment indicated that the chlorinated propanols contaminants were widely found in food contact papers in China.3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol were found to be typical chloropropanols contaminants in food contact papers(detection frequency were 65.1%and 30.2%,respectively),while 2-chloro-1,3-propanediol and 2,3-dichloro-1-propanol were also reported to be detected for the first time.The water extract level of chlorinated propanols in more than 50% of processing papers,kitchen papers and tissues didn’t comply with the limits proposed by the German Federal Risk Assessment Institute.The consumers groups with high exposure(P75,P95)to 3-chloro-1,2-propanediol derived from food contact papers exceeded the tolerable daily intake(TDI)proposed by the European Food Safety Agency.Thus,3-chloro-1,2-propanediol of food contact papers posed a potential health risk for consumers groups with high exposure.