Photocatalytic Decarboxylation Coupling Of Aromatic Carboxylic Acids And Photocatalytic Sulfides Synthesis Of Sulfoxides

With the rapid development of organic methodology,the traditional heating reaction seems to have been unable to satisfy the curiosity of chemists,seeking a new method to replace the traditional heating reaction has become one of the current research hotspots.And photocatalysis has been favored by many chemists due to its environmental friendliness,green,high efficiency,and renewable characteristics.Photocatalytic organic chemical reactions have become an important branch of organic synthesis methodology.The main way of photocatalytic reaction is to reduce the activation energy of the reaction under mild conditions to realize the SET between the catalyst and the substrate.With the continuous development of photocatalysis and the continuous development and application of new photocatalysts.Photocatalysis ushered in vigorous development.This paper reviews the latest research progress in this field,and related work has been carried out around photocatalytic decarboxylation coupling of aromatic carboxylic acid and photocatalytic sulfide synthesis of sulfoxide.Traditional aromatic carboxylic acid coupling reactions usually require higher reaction temperatures and transition metal catalysts,harsh reaction conditions and narrow substrate adaptation range.By photocatalyzing N-methyl-N-phenylanthranilic acid substrates,we realized the direct decarboxylation coupling reaction of aromatic carboxylic acid under photocatalysis for the first time.This strategy uses the equivalent of pyridine as a base to realize the self-coupling reaction of the decarboxylation of N-methyl-N-phenylanthranilic acid under the irradiation of the ultraviolet lamp without the need of a catalyst.The reaction substrate has a wide application range,is environmentally friendly and efficient,and provides a new way for the direct decarboxylation and coupling of aromatic carboxylic acids to synthesize carbazole.At the same time,we systematically studied the reaction mechanism through ultraviolet absorption experiment,silver mirror experiment,switch lamp experiment and KIE experiment.The sulfoxide functional group exists in many natural products.Because of its unique biological activity,it has a very wide range of applications in the field of organic synthesis.In the process of synthesizing sulfoxide,the transitional oxidation product of sulfoxide-sulfone is often obtained,so it is very necessary to choose a suitable oxidant.In the past,synthesizing sulfoxides often required equivalent oxidants and catalysts to work together,and the reaction conditions were more complicated.We have developed a method to directly synthesize sulfoxide from sulfide under the induction of visible light using 4Cz IPN as a photocatalyst.This strategy uses cheap and easily available sulfide compounds as starting materials,oxygen as a green oxidant,and mild reaction conditions.The reaction also has the advantages of no by-products and the catalyst can be recycled and reused efficiently.We also studied the reaction mechanism and further revealed the reaction process of sulfoxide synthesis from sulfoxide under photo-redox,providing a new way for the synthesis of sulfoxide compounds under mild conditions.