Study On Synthesis And Production Technology Of Urea-Formaldehyde Slow-Release Fertilizer,Buparvaquone And γ-Aminobutyric Acid

The research work in this dissertation consists of three parts: the synthesis and technology of novel urea-formaldehyde liquid slow-release fertilizer,the synthesis and technology of bovine veterinary drug buparvaquone,and the synthesis and technology of fertilizer synergistic agentγ-aminobutyric acid.The first part is the synthesis technology of urea-formaldehyde liquid slow-release fertilizer and the experimental study of fertilizer effect in field.Urea-formaldehyde slow-release fertilizer is the most widely used slow-release fertilizer in the world.Urea-formaldehyde slow-release fertilizer is difficult to volatilize and water-soluble.Urea-formaldehyde slow-release fertilizer can reduce the leaching loss of nitrogen in soil and ensure the nutrient absorption of plants in later period.In this dissertation,the synthetic route of urea-formaldehyde slow-release fertilizer was improved.The synthetic process takes formaldehyde and urea as raw materials and goes through "one pot method" to get urea-formaldehyde liquid slow-release fertilizer.The synthetic route uses low cost of raw materials,simple operation,and solves the problem of environmental pollution generated in the synthesis.In this dissertation,the process route studied from laboratory test to pilot test,and then to 300 kg scale experiment,and through the field fertilizer effect experiment,urea-formaldehyde liquid slow-release fertilizer can improve the yield of crops,providing a research basis for large-scale production of urea-formaldehyde liquid slow-release fertilizer.The second part is about the improvement of bupavarquone production process.Buparvaquone is a veterinary drug for the treatment of bovine Taylor pyrococcosis.The existing synthetic process has serious pollution,high production cost and low yield,so it is urgent to optimize the synthetic process of buparvaquone.Based on the synthetic route reported by Hudson,this dissertation improved the synthetic route of bupavarquone,optimized the synthetic process,and reduced the purification step in the post-treatment.bupavarquone was synthesized from p-tert-butylcyclohexanone through 7 steps of transformation.The total yield reached 67%and the purity of the product reached 99.7%.5 kg and 200 kg experiments were carried out,and the yield of amplification experiment was stable without obvious amplification effect.The third part is the synthesis and production process of γ-aminobutyric acid.γ-aminobutyric acid is widely found in plants and can also provide nutrients for plants,regulate their growth and development,and improve their stress resistance.In this part,the synthesis process of γ-aminobutyric acid was studied.After three stages of laboratory synthesis experiment,pilot production experiment and amplification production experiment,the synthesis process was optimized continuously to obtain γ-aminobutyric acid and γ-aminobutyric acid compound fertilizer.The process route starting from pyrrolidone raw material,through the "one pot method" synthesis of γ-aminobutyric acid,reaction temperature 150 ℃,reaction time 2 hours,to get γ-aminobutyric acid,the total yield is 89%.The process route has the advantages of simple operation and friendly environment.It laid the foundation for the popularization and application of γ-aminobutyric acid in fertilizer field.