Research On Non-invasive Blood Glucose Concentration Signal Extraction And Detection Device

Diabetes and its complications have become a global disease which is a serious threat to human health and even life safety.In the treatment of diabetes,continuous blood glucose monitoring plays an important role in guiding the rational use of drugs and reducing the occurrence of complications.Drawing venous blood or minimally invasive Fingertip blood sampling then adopt enzymatic method is general used by current medical to detect blood glucose,which increases the pain and economic burden of patients and fail to achieve continuous monitoring,therefore,in the reserch of better noninvasive detection methods and technology has become one of the hotspots in recent years at home and abroad.Near infrared spectrum is an important resource for detecting the chemical information of substances.Near infrared spectroscopy(NIR)is a technique for qualitative and quantitative analysis using near infrared absorption characteristics of sample components.This technique have advantages of no pain,no infection risk,fast measurement,no need of consumables and so on.It is considered as one of the most promising non-invasive methods.However,the current research on near infrared blood glucose detection is mostly based on near-infrared spectrometer,such large equipments,which with high detection cost.At the same time with large amount of data in the subsequent analysis,the utilization rate of that is low.Based on the problems above,a mathematical model is established between the glucose concentration and near infrared spectral data based on the in-depth study of near infrared noninvasive blood glucose detection theory and a large number of experimental analysis,use the near infrared LED lamp with a specific wavelength as the light source to find the main near infrared band which can reflect the glucose concentration information mostly to design a simple non-invasive blood glucose detection system.First of all,the level of blood glucose is mainly determined by the concentration of glucose in the blood.In the study of non-invasive blood glucose detection,the concentration of glucose solution is the basis of non-invasive blood glucose detection.Through the study of the basic experiments on the measure of glucose solution concentration between 100-1000mmol/L,using mass spectral data which measured by MB3000 Fourier transform near infrared spectrometer,the Longbow Bill law and the mathematical model between concentration and spectra by partial least square method,verified the feasibility of near-infrared glucose concentration detection.Then four specific wavelength,1050 nm,1550nm,1650 nm and 1750 nm,were found by combining theory and experimental results,finally finding the spectral data at four wavelengths from the full spectrum to establish the mathematical model,the results show that the glucose concentration can be completely characterized by the spectroscopy data of these four specific wavelength,the correlation coefficient of the model reached 0.95,detection error is between ?5 mmol/L.Based on the theoretical and experimental analysis above,a simple near infrared noninvasive blood glucose detection system was designed.With four specific wavelength of the LED lights as the near infrared light source,combined with the optical conduction structure and photoelectric detector to complete the optical design;circuit design including driving circuit of light source,photoelectric signal conversion circuit,signal amplifier,filter circuit and data acquisition circuit;software design using the collected data by the Lab VIEW software,with software filtering and processing,get the near infrared absorbance of the sample used for modeling research.The detection system is suitable for both in vitro blood glucose detection and in body signal extraction of human blood glucose.As for vitro test,the sample is placed in the 1mm cuvette sample pool,using transmission to collect data for modeling,model correlation is more than 0.9,thus the test of the concentration of solution in vivo detection can be achieved;As for the detection of the body,the dynamic spectrum method is used to collect the spectral data through the transmission of the fingertip,and the blood glucose signal can be extracted.This paper analyzes the band used in the NIR detection,a simple non-invasive blood glucose detection system is designed and realized the body detection of blood glucose concentration and the extraction of human blood glucose concentration signal,providing a reliable basis for the manufacture of near infrared nondestructive blood glucose analysis instrument.