Transcranial Electrical Stimulation System Compatible With Mri Environment

The brain is the headquarters of the human body and is vital to human beings.As early as the 20 th century,brain science has developed into an independent subject.The content of "China Brain Project" includes research in three aspects: brain and cognition,brain-computer intelligence and brain health.In recent years,the morbidity and mortality of neurological diseases on a global scale have been increasing year by year,and the health of the brain is particularly important.Studies have found that transcranial electrical stimulation has a certain effect on the treatment of such diseases,but its effects are not consistent.The reason is that the physiological mechanism of its action is not well understood.At present,there is no mature transcranial electrical stimulation system compatible with magnetic resonance environment in China.Therefore,this paper designs a transcranial electrical stimulation system compatible with the Magnetic Resonance Imaging(MRI)environment,and takes advantage of the high spatial resolution of MRI to prepare for further research on the mechanism of transcranial electrical stimulation.More precisely,the system designed in this paper provides a way to study how transcranial electrical stimulation regulates target brain regions and how to regulate the activity of the whole brain in the context of structural and functional connections.The transcranial electrical stimulation system compatible with the magnetic resonance environment designed in this paper can realize synchronous electrical stimulation and magnetic resonance imaging.It mainly includes three parts: the hardware and software of the transcranial electrical stimulator and the magnetic compatibility kit.The hardware part of the transcranial electrical stimulator can realize several types such as transcranial Direct Current Stimulation(t DCS),transcranial Alternating Current Stimulation(t ACS),pseudo stimulation,etc.,and can also realize impedance detection and real-time current monitoring.All parameters of the electric stimulator,including stimulation type,intensity,time,frequency,etc.,which can be directly set and displayed by touching on the Liquid Crystal Display(LCD).At the same time,the current monitoring data is displayed on the computer software in real time and an overcurrent warning is set.This article proposes solutions to the problems faced by the synchronization of electrical stimulation and magnetic resonance,selecting and designing compatible cables and electrode assemblies.In order to verify the feasibility of this system,this article carried out the performance index test and the verification of the magnetic compatibility kit for the electric stimulator,and finally carried out the synchronous t DCS and Functional magnetic resonance imaging(f MRI)experiment.This article first tested the load capacity,current accuracy,impedance detection,and system power consumption of the electric stimulator,and the relevant performance indicators have reached the current performance parameters of the domestic electric stimulator.Then,the feasibility of the system was verified from three aspects: safety,influence on electric stimulator,and influence on magnetic resonance imaging through water film experiment.Finally,this paper carried out synchronous electrical stimulation and magnetic resonance imaging experiments,and collected the functional imaging data of 14 subjects,three sets of data were collected for each subject that before,during and after stimulation.The results show that the system designed in this paper is feasible and effective.