Study On The Relationship Between Serum LAIR-1 And Rheumatoid Arthritis

Objective: Rheumatoid arthritis(RA)is a chronic,systemic autoimmune disease characterized by aggressive,symmetric polyarthritis.The main basic pathological change is chronic inflammation of the synovial membrane,leading to the formation of vasospasm,and the formation of articular cartilage and bone destruction,resulting in joint deformity and loss of function.This disease is one of the main causes of human labor loss and disability.RA is one of the major disabling diseases in our country,causing serious family and social burdens.So far,the pathogenesis of RA is still unclear,and the understanding of the initiation factors of RA pathogenesis is still incomplete,which is still a huge obstacle to the cure and prevention of RA.In recent years,it has been reported that the occurrence of rheumatoid arthritis is closely related to the inflammatory reaction and the destruction of osteoclast homeostasis.Leukocyte-associated immunoglobulin-like receptor-1(LAIR-1)is a transmembrane glycoprotein widely expressed in various immune cells such as T cells and B cells.Recent studies have shown that LAIR-1 is closely related to osteoclast differentiation,development and maturation,and osteoclast-mediated bone destruction is closely related to the inflammatory state in RA.Therefore,some scholars believe that LAIR-1 has a potential association with RA.Previous studies have examined the changes and clinical significance of serum LAIR-1 levels in patients with RA,but did not study the relationship between serum LAIR-1 levels and ultrasound assessment scores and X-ray assessment scores.This study measures the level of LAIR-1 in serum of patients with RA,and compares its relationship with disease activity,synovitis(ultrasound evaluation score),and bone destruction(X-ray assessment score)in patients with RA.To determine the relationship between LAIR-1 and RA disease activity,synovitis,etc.by measuring changes in serum LAIR-1 levels in RA patients,and to explore more effective and reliable RA laboratory indicators for RA treatment and disease assessment.It is of great significance.Methods: Sixty patients with rheumatoid arthritis,osteoarthritis(OA)and healthy controls were selected to detect ESR,CRP,tender joint count,swollen joint count,DAS28,ultrasound score,and X-ray score.Serum LAIR-1 levels were measured in RA patients,OA patients,and healthy controls.Results: Three groups of controlled trials meeting the inclusion criteria,a total of 180 patients,were divided into RA groups(including: RA high disease activity group,RA disease activity group,RA low disease activity group),OA group,healthy control group.Serum LAIR-1 expression was different in RA,OA and healthy controls(F=177.137,P<0.001).Serum LAIR-1 expression in RA patients was higher than that in osteoarthritis patients and normal subjects(P<0.05)..There were significant differences in serum LAIR-1 levels between the high,middle,and low disease groups in RA patients(15.28±2.31,10.47±1.85,7.77±1.72,P<0.001,respectively).Serum LAIR-1 levels and disease activity in the three groups.The degree of DAS28 and the number of joint tenderness and joint swelling were correlated(P<0.001).Serum LAIR-1 was associated with gray-scale ultrasound scores and energy Doppler ultrasound scores in patients with high and medium disease activity(P<0.05),and with gray-scale ultrasound-positive joint count and energy Dopplersonographic positive joint count.Relevant(P>0.05).There was no correlation between serum LAIR-1 and bone destruction(X-ray stage)in patients with high,medium and low disease activity(p>0.05).Conclusion: The level of serum LAIR-1 in patients with high and moderate disease RA is higher than that in patients with low disease activity,osteoarthritis and healthy people.The level of serum LAIR-1 in patients with RA was highly correlated with the number of joint swelling,the number of joint tenderness,DAS28,and the degree of ultrasound synovitis.Accordingly,it is suggested that serum LAIR-1 levels have value in the assessment of RA disease activity and can be used as a useful indicator to reflect the extent and extent of RA inflammation.And in the future to provide new ideas for the treatment of RA.