The Trends Of Clinical Epidemiology Of Upper Gastrointestinal Bleeding Inpatients In Recent 10 Years

Objective:To analyzed the trend of clinical epidemiology of upper gastrointestinal bleeding in this region in recent 10 years.Methods:The total of 4000 patients with "upper gastrointestinal bleeding"hospitalized in the Affiliated Hospital of Yanbian University were collected.Among them,1943 patients underwent gastroscopy.A comparative study was made on the etiology,inducement,gender,age,nationality and seasonal trend of 1943 patients.Results:1.From 2010 to 2019,there were 4000 patients diagnosed as "upper gastrointestinal bleeding" in the Affiliated Hospital of Yanbian University,among which 1943 patients underwent gastroscopy.There was a statistical difference in the change of the rate of gastroscopy in 10 years(p<0.05).The microscopic examination rate of upper gastrointestinal bleeding increased with time.2.The etiology of upper gastrointestinal bleeding in 1943 cases:the first is peptic ulcer 42.21%(820/1943),the second is esophageal-gastro varices 33.30%(647/1943),the third is acute gastric mucosal lesions 11.53%(224/1943)and the forth is malignant tumors 5.35%(104/1943),accounting for 92.38%(1795/1943)of all the causes of upper gastrointestinal bleeding.3.In 1943 patients with upper gastrointestinal bleeding,there was a statistically difference in the composition of gastric ulcer,acute gastric mucosal lesions and other causes changed with the year(p<0.05).There was no statistically difference in the composition of esophageal-gastro varices and malignant tumors changed with the year(p>0.05).The prevalence of gastric ulcer and acute gastric mucosal lesions was higher than before,and the prevalence of other causes was lower than before.4.In 1943 patients with upper gastrointestinal bleeding,566 had definite inducement.Among of them,337 patients took non-steroidal anti-inflammatory drugs,antiplatelet aggregation drugs and anti rheumatic drugs(such as aspirin,joint analgesics,etc.),60 patients took cold drugs,antibiotics,hormones,antidepressants,traditional Chinese medicine,health care products and other unknown drugs;162 patients drank heavily;5 patients took coarse or unclean diet;2 patients suffered from iatrogenic bleeding(caused by gastric polypectomy upper gastrointestinal bleeding).In the same period of time,the ratio of drug 1(non-steroidal anti-inflammatory drugs,etc.)was higher than that of drug 2(antibiotics,hormones,etc.),the difference was statistically significant(p<0.05).5.Among 1943 patients with upper gastrointestinal bleeding,1345 were male and 598 were female,the ratio of male to female was 2.25:1.There was no significant difference between the sexes of patients with upper gastrointestinal bleeding between 2010-2014 and 2015-2019(p>0.05).6.Among the 1943 cases of upper gastrointestinal bleeding,there were 1041 cases of Korean,873 cases of Han and 29 cases of other nationalities.In 2010-2014,compared with 2015-2019,there was a statistically significant difference in the composition of Korean and Han nationality(p<0.05).The prevalence of Korean nationality was lower than before,and the prevalence of Han nationality was significantly higher than before.7.In 1943 patients with upper gastrointestinal bleeding,the minimum age was 12 years,the maximum age was 92 years and the average age was 59.04± 13.31 years.In 2010-2014,compared with 2015-2019,there was a statistically difference in the composition of 46-60 years old group and≥61 years old group(p<0.05).Compared with different periods of time,the composition of ≥61 years old group was higher than that of 46-60 years old group.The average age of upper gastrointestinal bleeding increased from 58.34±13.11 years to 59.54 ±13.45 years,and there was statistical difference in the change of the average age(p<0.05).The average age of upper gastrointestinal bleeding is increasing.8.In the esophageal-gastro varices,the composition of 46-60 years old group was higher than that of ≤30 years old group and≥61 years old group,there was a statistically difference(p<0.05).In the malignant tumors,the composition of the group aged≥61 was higher than that of the group aged≤30 and 46-60(p<0.05).9.The incidence of peptic ulcer and esophageal-gastro varices were higher in autumn and winter than in summer,there was a statistically difference(p<0.05).10.1943 cases of upper gastrointestinal bleeding patients,13 patients with death,1930 patients with survival,death and survival groups of age,nationality,gender and seasons difference was no statistical difference(p>0.05).Conclusions:1.The top 4 causes of upper gastrointestinal bleeding in this region were peptic ulcer,esophageal-gastro varices,acute gastric mucosal lesions and malignant tumors.The prevalence of gastric ulcer and acute gastric mucosal lesions increased with the change of years,but the prevalence of esophageal-gastro varices and malignant tumors did not change significantly.2.Non-steroidal anti-inflammatory drugs and alcohol consumption are the main inducements of inpatients with upper gastrointestinal bleeding in this region.3.The related factors of the inpatients with upper gastrointestinal bleeding in this region include:age,nationality and season.4.The etiology,gender,age,nationality and season of upper gastrointestinal bleeding had no significant effect on the prognosis of patients.5.From 2010 to 2019,the microscopic examination rate of upper gastrointestinal bleeding in this region showed an increasing trend.