The Meta-analysis Of Risk Factors Of Cardiac Involvement With Systemic Lupus Erythematosus

Objective To investigate the risk factors of cardiac involvement with systemic lupus erythematosus(SLE)through meta-analysis,and provide evidence-based medical evidence for early detection,early diagnosis and early intervention of cardiac involvement in patients with systemic lupus erythematosus.Methods Search relevant literature on risk factors for cardiac involvement systemic lupus erythematosus in Chinese and English databases such as Chinese National Knowledge Infrastructure,Wanfang,and Weipu Chinese scientific journal databases,Pub Med,Em Base,the Cochrane Library,Literature publiccation time is limited to the establishment of the database until March 2020.According to the inclusion and exclusion criteria,the documents that meet the inclusion criteria are selected,and extracting data,and using Rev Man 5.3 software to perform meta-analysis on the included literature research results.Results There were 9 eligible documents included in this study,with a total people of 2571,1184 in the group of cardiac involvement with SLE,and 1387 in the group of non-cardiac involvement with SLE.1.The analysis results of gender and age : There is no statistically significant difference in the risk of cardiac involvement between female and male patients with SLE[OR=1.27,95%CI(0.97,1.65),P>0.05].Compared with the noncardiac involvement with SLE group,the age of the cardiac involvement with SLE group is older,and the result is statistically significant [MD=1.43,95%CI(0.28,2.59),P<0.05].2.The analysis results of disease duration and the time before using immunesuppressive agent: The time of the disease duration is not statistically significant between cardiac involvement and non-cardiac involvement with SLE patients[SMD=0.07,95%CI(-0.09,0.22),P>0.05].The time before using immunesuppressive agent is longer in cardiac involvement with SLE patients,and the result is statistically significant [MD=8.91,95%CI(7.42,10.40),P<0.05].3.The analysis results of the level of complement C3,ESR and CRP :Compared with the non-cardiac involvement with SLE group,the level of complement C3 is higher in cardiac involvement,and it’s statistically significant[SMD=-0.21,95%CI(-0.32,-0.11),P<0.05].The difference of ESR between the two group isn’t statistically significant [MD=9.42,95%CI(-7.80,26.63),P>0.05].The level of CRP in cardiac involvement with SLE patients is higher than control group [SMD=0.21,95%CI(0.01,0.40),P<0.05].4.The analysis results of SLEDAI: The difference of SLEDAI between the cardiac involvement with SLE group and the control group isn’t statistically significant [MD=2.84,95%CI(-0.73,6.42),P>0.05].5.The analysis results of autoantibodies: It is no statistically significant between the cardiac involvement with SLE group and the control group which is the difference of antinuclear antibody,ds-DNA antibody,anti-SSA antibody,antiSSB antibody,anticardiolipin antibody(P>0.05).Conclusion Low complement C3,increased CRP,and age and longer time before using immunosuppressive agent are the risk factors for cardiac involvement with SLE.