| Objective:To investigate the prevalence of metabolic diseases among the14656 healthy clinical trial subjects,and to learn about their demographic characteristics and major influencing factors related to the metabolic diseases,so as to provide a scientific basis for targeted health education and management.Method:A total of 14,656 healthy subjects with complete records were selected from 95 clinical trials in Phase I Clinical Research Center of the First Hospital of Jilin University from 2012 to 2019.Physical examination included vital signs,simple physical examination,blood and urine routine,liver and kidney function,dyslipidemia,blood glucose,uric acid,Infectious marker,abdominal B-ultrasound.Excel was used for logging data.SPSS 21.0 statistical software was used for statistical analysis according to the diagnostic criteria of each disease.Chi-square test was used to compare the prevalence of chronic diseases,trend chi-square test was used to analyze the change trend of the rate.Logistic regression analysis was used to analyze the influencing factors.Result:1.The top five of diseases were overweight/obesity,dyslipidemia,hyperuricemia,fatty liver,hypertension.The prevalence was 25.8%,12.1%,11.8%,10.1%,7.5%,respectively.The prevalence of overweight/obesity were 18 to 29 years old(20%),30 to 39 years old(25.7%),40 to 49 years old(29.5%)and 50 to 61 years old(41.4%),respectively.The prevalence of dyslipidemia was 9.8% in 18 to 29 years old,12.1% in 30 to 39 years old,13.3% in 40 to 49 years old,and 23.7%in 50 to 61 years old.The prevalence of hyperuricemia in different age groups was 14.7%,10.9%,9.9% and 16.5%,respectively,in 18-29 years old,30-39 years old,40-49 years old and 50-61 years old.The prevalence of fatty liver in different age groups was 18 to 29 years old(7.5%),30 to39 years old(10.1%),40 to 49 years old(12.3%),50 to 61 years old(20.8%).The prevalence of hypertension in each age group was 5.7%(18-29 years old),6.9%(30-39 years old),9.2%(40-49 years old),and17.8%(50-61 years old).2.The risk factors of dyslipidemia were hyperglycemia(OR=4.394),fatty liver(OR=4.056),hyperuricemia(OR=3.549),elevated GGT(OR=3.182),elevated ALT(OR=2.433),40 to 49 years old(OR=1.449)and 30 to 39 years old(OR=1.236).3.The risk factors for hyperuricemia were male(OR=4.701),low high-density lipoprotein(OR=3.256),fatty liver(OR=2.590),hypertriglyceridemia(OR=2.257),elevated ALT(OR=2.255),hyperglycemia(OR=2.138),hypercholesterolemia(OR=1.993),and elevated GGT(OR=1.945).The protective factors for hyperuricemia were30 to 39 years old(OR=0.581),40 to 49 years old(OR=0.567),and 50 to61 years old(OR=0.380).4.The risk factors for fatty liver were male(OR=6.477),hyperglycemia(OR=3.751),hypertriglyceridemia(OR=3.082),hyperuricemia(OR=2.834),50 to 61 years old(OR=2.804),low highdensity lipoprotein(OR=2.621),high-density lipoprotein(OR=2.557),hypercholesteremia(OR=2.271),elevated ALT(OR=2.115),40 to 49 years old(OR=2.071),elevated GGT(OR=1.591),30 to 39 years old(OR=1.587).Conclusion:1.The top five metabolic diseases of 14656 healthy clinical trial subjects in this study were overweight/obesity,dyslipidemia,hyperuricemia,fatty liver,and hypertension.2.In this study,the prevalence of hyperuricemia in metabolic diseases in healthy subjects was higher than that in most areas,and the prevalence of overweight/obesity,dyslipidemia,fatty liver and hypertension were lower than that in the national level.There was no significant difference in the prevalence of overweight/obesity between males and females.The prevalence of dyslipidemia,hyperuricemia,fatty liver and hypertension was higher in males than in females.The prevalence of hyperuricemia decreased first and then increased with age,while the prevalence of overweight/obesity,dyslipidemia,fatty liver and hypertension showed an increasing trend with age.3.The main influencing factors of metabolic diseases in this study were gender,age,hyperglycemia,hyperuricemia,fatty liver,triglyceride,cholesterol,high density lipoprotein,low density lipoprotein,ALT,GGT levels. |
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