Functionalized Hydrogel For The Diagnosis And Treatment Of T2D And Its Complications

As polymer network systems containing a large amount of water in the matrix,hydrogels have been widely used in many fields such as biology and medicine due to its similarity to extracellular matrix components,and its contact with blood,body fluids,and human tissue does not affect the metabolic processes of living organisms.However,due to the lack of unique physical properties of traditional polymer hydrogels,its further application in high-end fields is limited.With the development of research,a series of hydrogels with special physical properties have improved this situation to a great extent.At the same time,the progress of research on the biocompatibility and biodegradability with hydrogels,which were expected to be used in the field of biomedicine,is also worthy of attention.This thesis introduces several hydrogels with special structures and the mechanisms for improving their physical properties.Moreover,a discussion will be made around specific methods for imparting special physical properties to hydrogels and applications in the field of biomedicine such as surgery,tissue engineering,and drug release.In the medical field,type 2 diabetes(T2D)is a genetically heterogeneous disease with a high prevalence rate.Due to the pathological changes of capillaries,people with diabetes can easily lead to multiple complications such as skin ulcers,skin defects,and wet fundus macula.The second chapter of this thesis proposed a simplified T2 D diagnosis method through sample analysis and simulation diagnosis;and utilized literature research,retrospective research and other methods to explore the potential value of functionalized hydrogels in T2 D diagnosis,which provided new ideas for the further simplification of T2 D diagnosis.In the third chapter of this thesis,the in-situ moldable M-CMCS/O-HES(Modified Carboxymethyl Chitosan/Oxidized Hydroxyethyl Starch)hydrogel was prepared.M-CMCS/O-HES has excellent self-healing,biocompatibility,biodegradability and transparency that can accelerate wound healing.Compared with the non-treatment control group,the superficial skin defect under the intervention of M-CMCS/O-HES hydrogel showed higher wound closure rate,more granulation tissue and epithelial tissue formation and low level of collagen deposition.The results indicated that the as prepared M-CMCS/O-HES gel has certain potential application value in the treatment of difficult-to-heal skin defects accompanied by diabetes.The fourth chapter of this thesis discussed a PVA/Gel MA(Polyvinyl alcohol/Gelatin-methacryloyl)hydrogel.PVA/Gel MA can carry strong permeability DSP(Dexamethasone Sodium Phosphate)in situ and be cross-linked and cured into the shape of contact lens.The results showed that PVA/Gel MA has good light transmission,drug release characteristics,cell compatibility,resistance to degradation and biocompatibility.In potential applications,the entire gel system can carry anti-VEGF drugs through further swelling effect,and use the strong permeability of the released DSP to make anti-VEGF drugs act in the vitreous.The contact lens-like drug delivery system based on PVA/Gel MA hydrogel,is expected to treat fundus macula through non-invasive drug delivery.