| Background and objective:Diabetes mellitus has a wide prevalence in the population,which brings great pain to patients and great economic burden to the whole society.In this study,serum growth hormone and IGF-1 were measured in patients with type 2 diabetes mellitus,and body mass index,abdominal circumference,body fat percentage,waist-to-hip fat ratio,etc.were also measured.Through this study,the relationship between abdominal obesity,insulin resistance,abdominal fat and growth hormone,IGF-1was further explored.Methods:1.Study subjects: This study was a prospective study.100 hospitalized patients with type 2 diabetes and abdominal obesity in the Department of Endocrinology and Metabolism of the Second Affiliated Hospital of Nanchang University from July2020 to December 2020 were included,and 100 patients with type 2 diabetes alone were included as controls.There was no significant difference in the age and gender of the investigators in the control group compared with the patients.2.Study grouping: The patients were divided into type 2 diabetes with abdominal obesity simple type 2 diabetes group according to the criteria of abdominal obesity: female waist circumference ≥ 80 cm,male waist circumference ≥ 85 cm;3.Test indicators:the information of the two groups of researchers was collected,including gender,age,medical history,etc.;physical indicators were examined,including weight,height,waist circumference,waist-to-hip ratio,waist-to-body ratio,BMI,etc.;serum growth hormone,IGF-1,blood lipids,fasting blood glucose,1-hour blood glucose,2-hour blood glucose,glycosylated hemoglobin,fasting serum insulin,1-hour serum insulin,2-hour serum insulin,liver function,hepatic steatosis quantification,renal function,urinary microalbumin,body fat rate,etc.4.data analysis: SPSS 23.0statistical software was used for statistical analysis.There was no significant difference in age,gender,height and other general clinical information between the two groups(P > 0.05).The body weight of the subjects in the most two groups(64.48 ± 7.71 vs.75.12 ± 5.63),waist circumference(male: 82.99 ± 9.1 vs.94.28 ± 12.1;female: 77.71 ± 11.2 vs.90.65 ± 6.12),body mass index(23.19 ± 1.5 vs.27.19 ± 2.1)waist-to-hip ratio(male: 0.78 ± 0.19 vs.0.92± 0.19;female: 0.74 ± 0.22 vs.0.88 ± 0.45)contrast data showed that there was a significant difference between the values of the control study group with type Ⅱ diabetes and obesity,P < 0.05;the growth hormone level of patients with type 2.2diabetes and abdominal obesity was significantly higher than that of the control group(7.24 ± 0.09 vs.5.17 ± 0.19,P < 0.05).Meanwhile,the IGF-1 detection level of patients with type 2 diabetes and abdominal obesity was significantly lower than that of the control group(125 ± 12.08 vs 136 ± 12.21,P < 0.05).Total cholesterol levels in subjects with type 3.2 diabetes and abdominal obesity(5.0 ± 0.3 vs.5.2 ± 0.5,P =0.01),triglyceride levels(1.5 ± 0.2 vs.1.8 ± 0.1,P = 0.01)and low-density lipoprotein cholesterol levels(1.6 ± 0.2 vs.3.3 ± 1.2,P = 0.01)was significantly higher than that in the control group of patients with simple type 2 diabetes.There was also a significant difference in blood glucose levels between patients with abdominal obesity and controls,and their blood glucose levels were significantly higher than those in controls(6.7 ± 0.3 vs.4.7 ± 0.1,P = 0.003),and insulin was significantly lower in type Ⅱ diabetic patients with obesity than in controls(1250 ±125 vs.1798 ± 260,P = 0.017).4.Some patients with type 2 diabetes and abdominal obesity had excessive liver test parameters,but no significant difference was found between the two groups.Liver fat quantification was significantly higher in patients with type 2 diabetes and abdominal obesity than in controls(244 ± 41.0 vs.206 ±23.1,P = 0.012)and was higher than the standard value of 238.The renal function indicators of subjects in both groups showed different levels of increase,and the difference was statistically significant;5.Multiple linear regression analysis showed that body mass index and waist circumference were independently correlated with growth hormone and IGF-1(p = 0.04),in addition,no correlation was observed between midabdominal hip ratio,waist-to-hip ratio and growth hormone/IGF-1levels in patients with type Ⅱ diabetes.Conclusion:There is a significant correlation between growth hormone/IGF-1 and type 2diabetic patients with abdominal obesity,and patients with abdominal obesity have a higher probability of facing impaired liver and kidney function than patients with simple type 2 diabetes. |
