Renal Insufficiency In Chinese Patients With Aldosterone-producing Adenoma And Bilateral Adrenal Hyperplasia

Objective1.Primary purpose: To investigate the difference of renal insufficiency between Aldosterone-producing Adenoma(APA)and Bilateral adrenal hyperplasia(BAH).2.Secondary purpose: To investigate the difference of renal insufficiency between PA and essential hypertension in Chinese population and determined the risk factors in association with renal insufficiency.MethodsWe compared the prevalences of albuminuria and estimated glomerular filtration rate(e GFR)between patients with APA(N=558)and sex and age matched BAH(N=365).We compared the prevalences of albuminuria and estimated glomerular filtration rate(e GFR)between patients with PA(N=558)and sex and age matched essential hypertension(EH)(N=365).Logistic regression analysis was used to identify parameters that increase the risk for these renal impairments.ResultsThe prevalence of albuminuria in patients with aldosterone-producing adenoma(APA)was higher than that of bilateral adrenal hyperplasia(BAH)patients(51.5% VS.37.5%),P=0.034,whereas there was no statistical difference between two groups in the prevalence of e GFR < 60 m L/min/1.73 m2(7.6% VS.10.6%),P=0.278.Among the 558 PA patients,the prevalences of albuminuria and e GFR were 44.6% and 9.7%,respectively.The prevalence of albuminuria was significantly higher than that of matched EH patients(44.6% VS.22.5%),P=0.000.The prevalence of e GFR < 60 m L/min/1.73 m2 was also higher than that of matched EH patients(9.7% VS.4.2%),P=0.011.The logistic regression analysis showed that subtype of APA and plasma aldosterone concentration increases the risk of albuminuria.ConclusionThe prevalence of albuminuria in patients with APA was higher than that with BAH.The subtype of APA and Plasma aldosterone concentration may be risk factors for albuminuria.