The Predictive Value Of The Combined Detection Of CRP/ALB Ratio,Lactate Dehydrogenase And Serum Calcium For The Severity Of Early Acute Pancreatitis

ObjectiveTo investigate the predictive value of the combined detection of CRP/ALB ratio,lactate dehydrogenase（LDH）and serum calcium for the severity of early AP.Methods138 patients with acute pancreatitis admitted to our hospital from July 2018 to June2021 were selected.Patients were divided into two groups:（1）the group of mild acute pancreatitis（MAP）combined with moderately severe acute pancreatitis（MSAP）,n=100;（2）the group of severe acute pancreatitis（SAP）,n=38,according to the Atlanta International Consensus on Acute pancreatitis revised in 2012.The single-factor was used to screen out the indicators related to the severity of early AP,and the multi-factor analysis Logistic regression was used to screen out the independent risk factors which affected the severity of early AP.To evaluate the predictive value of CRP/ALB ratio,LDH,serum calcium and their combined detection in stratification of the severity of early AP by the receiver operating characteristic.Results（1）Compared with the group of MAP combined with MSAP,the heart rate,respiratory rate,CRP,HCT,D-dimer,PCT,serum amylase,serum creatinine,AST,total bilirubin,LDH,ALB and CRP/ALB ratio in SAP group were significantly increased,ALP was slightly decreased,and serum calcium was significantly decreased（P<0.05）.（2）LDH（OR=1.002,95%CI:1.001-1.003）,serum calcium（OR=0.134,95%CI:0.027-0.676）,and CRP/ALB ratio（OR=1.727,95%CI:1.291-2.310）were independent risk factors for SAP（P<0.05）.（3）The combined detection of CRP/ALB ratio,LDH and serum calcium had the highest value in predicting the stratification of the severity of early AP.ConclusionThe combined detection of CRP/ALB ratio,LDH and serum calcium has high predictive value for the classification of the severity of early AP.