Retrospective Analysis Of 541 Cases Of Infectious Mononucleosis In Children Based On Five Circuits And Six Qi Theory

ObjectiveTo understand the symptoms and signs,complications or complications of pediatric infectious mononucleosis(IM),laboratory tests,and the distribution of the factors of birth and morbidity,and to investigate the birth and morbidity of children with IM.The correlation between time and five circuits and six qi and its associated liver damage,and the establishment of a predictive model,provide a reference for early clinical diagnosis and prevention.MethodThe case data of the diagnosis of IM admitted to the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and Qilu Hospital of Shandong University from 2003 to 2018 were selected.The database of children with IM and primary EBV infection was established by layer-by-layer data screening,and IBM SPSS Statistics software was used for retrospective analysis.Result1.Among the 541 children with IM,337(62.3%)were male and 204(37.7%)were female,more male than female(P<0.01);the prevalence of preschool children was higher(P<0.05).2.There were 46 complications or comorbidities in IM,involving 7 major systems.The proportion of complications or comorbidities in each system was different.The digestive system and respiratory diseases such as liver function damage and pneumonia were the main complications(P<0.05).3.The percentage of lymphocytes in the IM group was higher than that in the symptomatic EBV-infected group.The percentage of monocytes in the EBV-infected group was higher than that in the asymptomatic EBV-infected group.The load of EBV-DNA in plasma was higher than that in the symptomatic and asymptomatic EBV-infected group(pairwise comparison,the corrected P values were<0.05).4.There was no significant difference in the distribution of birth,onset month and season of children with IM(P>0.05).5.The primary circuits and primary qi of birth,heaven qi,controlling heaven qi,object circuits and object qi of onset date of children with IM was significantly different(P<0.05).6.There was no significant difference in the distribution of gender,age,age group,birth and onset month and season between liver damage group and non-hepatic damage group(P>0.05).7.The liver damage group and the non-hepatic damage group were different in the distribution of the birth heaven qi and controlling heaven qi(P<0.05).To the extent of relevance,the number of links was 0.182 and 0.157.8.The probability of liver damage in children with IM born to Shaoyang Xianghuo was 2.66 times than that of the Jueyin Fengmu(OR=2.66,95%CI,1.331-5.318,P<0.01).9.Logistic regression equation of IM complicated with liver damage:Logit(P)=-1.78+B(partial regression coefficient of each controlling heaven qi of birth date),the overall prediction accuracy of the model is 83.2%.Conclusion1.Children with IM have different laboratory tests from children with or without symptomatic primary EBV infection.The clinical diagnosis of IM may refer to the load of EBV-DNA in plasma samples.2.The incidence of IM was independent with the season and month of birth and onset.3.IM children have the characteristics of five circuits and six qi4.Gender,age,birth and onset months,seasons,and hospital stay days were not associated with IM-induced liver damage.5.The controlling heaven qi of the birth date of children with IM is associated with concurrent liver damage.Among them,the probability of liver damage in children with IM who are born with Shaoyang Xianghuo is higher.6.The predictive model of IM with the probability of liver damage was constructed.The overall prediction accuracy of the model was 83.2%.