| Objective This study aimed to assess the impact of Qingxuanhuoxue-decoction,a Chinese herbal formula,for functional endoscopic sinus surgery(FESS)in patients(damp-heat with blood stasis symptom)with chronic rhinosinusitis with nasal polyp(CRSw NP).To evaluate the postoperative efficacy of Qingxuanhuoxue-decoction in patients with CRSw NP(damp-heat with blood stasis symptom)after FESS from the change of mucociliary transport time(MTT),and to provide part of the basis for the effectiveness of Chinese medicine in the postoperative application of CRSw NP.Methods A total of 64 patients who had signed the informed consent and met the inclusion criteria were included and randomly divided into treatment group and control group at 1:1.The perioperative treatment plan(antibiotic and hormone drug application,nasal irrigation treatment)was the same,FESS was performed by the same experienced and skilled doctor with Messerklinger operation,and necessary intraoperative treatment was conducted according to the situation of the operative cavity.The baseline was 1 week after surgery(before observation and treatment,hereinafter referred to as treatment).The control group was given saline nasal irrigation and budesonide nasal spray nasal spray,and the treatment group was given " Qingxuanhuoxue-decoction",Oral administration on the basis of the control group.The two groups received a course of 12 weeks each.Relevant data were recorded:(1)Visual Analogue Scale(VAS)score of subjective symptoms of patients in the two groups before treatment and 12 weeks after treatment;(2)Lund-Kennedy(L-K)endoscopic score of patients in the two groups before treatment,at week 2,4,8 and 12;(3)MTT before treatment,at week 2,4,8 and 12.The collected data were then sorted out,statistically analyzed using SPSS22.0.Results All of cases were completed except four subjects were rejected.1 Overall ResponseThe total effective rate of the treatment group was 93.33%,which was better than that of the control one was 73.33%(P<0.05).2 VASAfter 12-weeks treatment,The VAS total score and single item score show significant improvement from baseline in two groups(P < 0.05),but the treatment group is more significant(P<0.05).3 L-KCompared to before treatment,The single score of mucosal edema,rhinorrhea,scar and Scab and total score in two groups were differences from baseline(P<0.05).Compared to the control group,The single score of edema and rhinorrhea of L-K in treatment group were significantly better than that of the control one at week 2,4(P<0.05),The single score of the rhinorrhea was better than that of the control group(P<0.05).The single score of polyp were better than the control group at week 4,8(P<0.05).There were no significant difference between the LK total scores and the single score of the two groups after 12-weeks treatment(P>0.05).4 MTTCompared to before treatment,The mucociliary transport time(MTT)in two groups were significant differences from baseline(P<0.05).There were no significant differences between the treatment group and the control group at 2th,4th week in MTT(P>0.05),The treatment group was superior to the control group at8 th and 12 th week of treatment(P<0.05).Conclusion1 Qingxuanhuoxue-decoction could reduce postoperative clinical VAS symptom score and L-K endoscopic score in patients with CRSw NP(damp-heat with blood stasis symptom),Explain that Qingxuanhuoxue-decoction could improve postoperative symptoms and accelerate postoperative mucosal recovery.2 Qingxuanhuoxue-decoction could reduce the MTT and promote the recovery of mucociliary transmission function.3 According to the clinical observation,the application of Qingxuanhuoxue-decoc tion in the treatment of patients after CRSw NP(damp-heat with blood stasis sy mptom)is effective and worthy of clinical promotion. |
PDF Full Text Request