Study On Prepration Technology And Quality Standard Of Classical Famous Prescription Banxia Xiexin Decoction

Banxia Xiexin Decoction is part of Classical Famous Prescription.Its prescriptions are rigorous and streamlined,and its effects are conscientious.Nowadays,to meet the medical demands of China and urge the improvement of traditional Chinese medicines,our country facilitates classic famous prescriptions positively.Chinese medicines come from classic famous prescriptions could be scrutinized and examined simply.This study is guided by the theories of conventional Chinese medicine,and match with modern tech,which studies banxia xiexin decoction systematically in preparation tech and quality standards.This study will provide experience for many corporations.1)Study on the preparation process of Banxia Xiexin DecoctionAccording to the current edition of the Chinese Pharmacopoeia and the corresponding recent research,the basis for the use of pieces of Banxia xiexin decoction has been fixed: Pinellia is a dry tuber of the Asteraceae plant Pinellia ternata;ginseng is the dried root and rhizome of the quince family plant.;Scutellaria baicalensis is the dried rhizome of Labiatae Scutellariae;Pistacia chinensis is the dried rhizome of Ranunculaceae plant Pistacia chinensis;Dried ginger is the dried rhizome of Zingiberaceae;Glycyrrhiza is a processed product of the legume Glycyrrhiza;and Jujube is the Rhamnaceae The dried and mature fruits of the plant date.Medicinal materials of Pinellia ternata and licorice need to be processed according to the original records of Typhoid Fever.Among them,Liquiritin is processed according to the current version of the Chinese Pharmacopoeia.Specific operating methods,but there is no such item in the current version of the Chinese Pharmacopoeia,and the safety of clinical medication cannot be guaranteed.The literature has confirmed that Jiang Pinxia is highly safe and available to pregnant women.Therefore,the "washed pinellia" was changed to ginger pinellia.Chinese Pharmacopoeia method.Through the exploration and verification of the remaining medicinal solution in the decoction pot,a preparation process consistent with the original record of Febrile Diseases was established: Weighing 12 g of pinellia decoction pieces and 9g of scutellaria baicalensis decoction pieces.9 g of ginseng decoction pieces,9 g of ginseng decoction pieces,9 g of licorice decoction pieces,3 g of coptis decoction pieces,4 jujubes,placed in a ceramic pot of decoction,add 2000 m L of water,and use an electric ceramic oven 2200 W to heat and cook for 21 minutes.Reduce heating power to 800 W and continue to cook for 50 min.After the cooking is complete,the medicine liquid passes through the No.9 sieve,discard the Chinese medicine residue in the medicine pot,and return the medicine liquid to the medicine pot.Continue to heat and cook at 2200 W.After boiling Keep it for 37 minutes,that’s it.2)Study on the quality standard of Banxia xiexin decoctionPrepare 15 batches of Banxia xiexin decoction standard decoction and lyophilized powder from different origins.Establishing specific fingerprints.According to the research results,the fingerprints among different batches enjoys a pretty high similarity(more than 0.9),of which there are 18 peaks and 7 are identified,which are liquiritin,liquiritin apioside,baicalin,berberine,wogonoside,glycyrrhizic acid,6-gingerol,negative The control determined the assignment of each peak,and the 18 common peaks were from licorice,scutellaria baicalensis,Coptis chinensis,and dried ginger.Based on the results of the content determination of the decoction pieces and the substance standard,the range of the index component transfer rate was determined:the liquiritin transfer rate was 25.90% to 48.11%,the baicalin transfer rate was26.06% to 48.40%,and the berberine transfer rates were 40.58% to 75.35.%(70% ～130% of the mean).Calculate the paste rate based on the weight of the corresponding physical(freeze-dried powder),and the rate of paste output ranges from 22.35% to41.51%(average 70% to 130%).According to the measurement results of the corresponding physical content,determine the day of Banxia xiexin decoction The dose should contain 36.1 to 72.5 mg of liquiritin,449.4 to 871.9 mg of baicalin,and84.3 to 136.5 mg of berberine(70%～130% average value of physical measurement results).15 batches of Banxia xiexin decoction corresponding physical objects were analyzed by Desorption Electrospray Ionization-Mass Spectrometry Imaging(DESI-MSI),and 22 chemical components from liquorice,coptis,scutellaria baicalensis,jujube and ginseng,were determined.And the relative content of each component in different samples was semi-quantitatively analyzed by calculating the peak height value.Liquiritin,baicalin and UHPLC-DAD method have a strong correlation with the results of the content determination.The MSI technology can be used for the classical famous prescription banxia xiexin decoction.Finally,this study establishes quality standards of 15 batches banxia xiexin decoction and a new method of quality control for classic famous prescriptions,which provide experience for many corporations.