The Clinical Effect Of Yougui Pill In Treating Oligomenorrhea Of Kidney-yang Deficiency Type Combined With Thin Endometrium

Object In this study,this study intends to adopt a pre-and post-treatment self-control method,based on the basic pathogenesis of patients with oligomenorrhea due to kidney-yang deficiency and thin endometrial patients,and use the typical symptom of thin endometrial-oligomenorrhea as the entry point.To observe the clinical effect of Yougui Pill on patients with oligomenorrhea due to kidney-yang deficiency and thin endometrium.Method A total of 42 patients who met the inclusion criteria were selected and treated with Yougui Pill.The drug composition of Yougui Pill(according to the proportion of the original prescription): prepared rehmannia 24 g,aconite(processed aconite)10g,cinnamon 6G,yam 12 g,Cornus officinalis 9g,Cuscuta 12 g,antler gum 12 g,Lycium barbarum 9g,Danggui 9g,Eucommia ulmoides(salt fried)12g,decoction,one dose a day.Starting from the menstrual period,the medication lasted for 21 days.Three menstrual cycles were used.Observation of patients before and after treatment(1)menstrual volume score: menstrual volume score mainly includes menstrual volume,menstrual color,menstrual quality and menstrual line time.In menstrual volume score,if the menstrual volume is normal > 30 ml,the score is 0;if the menstrual volume decreases by 1/ 3 or < 20 ml,the score is 1 point;if the menstrual volume decreases by2 / 3,it is 2 points;if the menstrual volume is normal,the menstrual quality is 1 point,and the dark red color is 2 points The duration of 3-7 days was 0 points,2-3 days was 1 point,and less than 2 days was 2points.(2)TCM symptom score: the kidney yang deficiency symptom score is mainly evaluated by the symptoms of soreness and weakness of waist and knee,fear of cold and cold,cold pain of small abdomen,clear amount of leucorrhea and nocturia.The score is 0-3,0 is asymptomatic,1 is occasional,2 is regular,and 3 is persistent non remission.(3)Endometrial thickness measurement: before treatment and after 3 menstrual cycles,the endometrial thickness was measured and recorded when the maximum follicle diameter was ≥ 18 mm on the 13 th to 17 th day of the menstrual cycle.After the treatment,the clinical efficacy was observed.The specific evaluation criteria were as follows: ineffective: the endometrial thickness in the middle luteal phase(follicle mature to18mm)was less than 7mm,the menstrual volume was not improved and the clinical symptoms were not relieved.Effective: endometrial thickness ≥7mm in the middle luteal phase(follicle mature to 18mm),the menstrual volume was improved and the clinical symptoms were alleviated.Significant effect: endometrial thickness ≥ 8mm in the middle luteal phase(follicle mature to 18mm),significantly increased menstrual volume and improved clinical symptoms compared with before treatment.Recovery:in the middle luteal phase(follicle mature to 18mm),endometrial thickness ≥ 9mm,menstrual volume returned to normal,clinical symptoms disappeared.Result The average age of 42 patients was(30.28 ± 2.41)years old,including 6 patients aged 20-25 years,30 patients aged 26-30 years,4patients aged 31-35 years,and 2 patients aged 36-40 years.The course of disease was between February and 20 months,with an average duration of(7.32 ± 1.43)months.The course of disease ranged from February to may,16 from June to October,9 from November to 15 and 3 from 16 to 20 months.After treatment,the menstrual volume,menstrual color and quality,menstrual time and total score of menstrual volume in 42 patients were significantly improved compared with those before treatment,and the difference was statistically significant(P < 0.05).After treatment,the waist and knee soreness,chilly and afraid of cold,small abdomen cold pain,clear leucorrhea,nocturia and total symptom scores of 42 patients were significantly improved compared with those before treatment,the difference was statistically significant(P < 0.05)0.05)。 The endometrial thickness of 42 patients was(5.52 ± 0.13)mm and(8.47 ± 0.22)mm after treatment when the maximum follicle diameter was ≥ 18 mm,and the difference was statistically significant(P <0.05).Among the 42 cases,1 case was cured,19 cases were markedly effective,18 cases were effective and 4 cases were ineffective.Conclusion(1)Yougui pill can effectively improve menstrual flow,menstrual color and quality,and menstrual time in patients with kidney-yang deficiency type oligomenorrhea and thin endometrium;(2)Yougui pill can effectively improve the clinical symptoms of kidneyyang deficiency in patients with kidney-yang deficiency type oligomenorrhea and thin endometrial patients,such as lumbar and knee weakness,chills and chills,lower abdomen pain,clear vaginal discharge,and nocturia;(3)Yougui pill can effectively improve the endometrial thickness of patients with oligomenorrhea due to kidney-yang deficiency and thin endometrial.(4)Although the results of this study show that Yougui Pill can effectively improve the clinical symptoms of patients with kidney-yang deficiency type oligomenorrhea and thin endometrial patients,increase the patient’s menstrual volume,and increase the thickness of the endometrium,but for this study,the research design There are certain limitations,as follows: The lack of a control group in this study may be biased towards the results of the study;lack of long-term clinical efficacy observation.Therefore,in future clinical studies,the research design plan can be optimized,the current positive drugs for the treatment of this disease can be added as a control,and the long-term clinical efficacy observation should be strengthened,and a more scientific evaluation of the Yougui pill in the treatment of kidney-yang deficiency combined with oligomenorrhea The clinical efficacy of patients with thin endometrium.