| Persistent postural perceptual dizziness is a kind of dizziness with a long duration and no-rotating.It is easy to cause persistent dizziness and standing instability in upright posture,self-motion and exposure to visual motion stimuli,and generally has no vestibular dysfunction.Persistent postural perceptual dizziness is a common chronic dizziness,most of the patients with anxiety and depression,affecting the quality of daily life.The drug therapy mainly consists of neuropsychiatric selective serotonin reuptake inhibitors(SSRIs)(on behalf of the drug Escitalopram oxalate tablets),serotonin,norepinephrine reuptake inhibitors(SNRIs)(on behalf of the drug duloxetine hydrochloride enteric capsules).however,there are few studies on the comparative study of the two kinds of drugs at home and abroad.this study designed an experiment to compare the efficacy of the two drugs,so as to provide a basis for the repeated irregular medication and the patients with severe disease of the drug choice.60 patients with persistent postural perception dizziness were randomly divided into two groups: group A(30 cases)treated with Escitalopram oxalate tablets,biofeedback cognitive behavioral therapy and vestibular rehabilitation,and group B(30 cases)was with Duloxetine hydrochloride enteric capsule,biofeedback cognitive behavioral therapy and vestibular rehabilitation treatment.And all the 60 patients in the study were assessed by DHI,HADS and SF-36 before treatment and at the end of treatment 2,4 and 6 weeks.At 4th and 6th week,There were statistically significant differences in scores of the three scales both groups A and B compared with those before treatment(P<0.05);the three scales scores were statistically significantly between the group A and group B(P<0.05)[group A: 4th week: DHI(40.20±16.70),HADS(10.77±6.42),6th week: DHI(30.97±15.13),HADS(8.13±6.42).group B: 4th weeks: DHI(31.93±13.24),HADS(7.00±3.56).6th weeks: DHI(19.33±10.24),HADS(4.43±3.27),(P <0.05)].SF-36 including eight aspects: physiological function,role-physical,bodily-pain,general health,vitality,social-functioning,role-emotional,and mental health,[group A:4th weeks:(74.63±6.01),(41.67±32.39),(76.83±17.90),(50.33±16.08),(60.67±17.11),(65.00±20.61),(50.00±34.75),(65.47±13.51).6th weeks:(88.33±9.59),(71.67±21.51),(86.00±11.79),(73.83±11.27),(80.50±8.94),(80.83±13.83),(66.68±29.04),(80.53±10.58).group B: 4th weeks:(78.83±7.39),(64.17±22.44),(86.33±7.37),(68.17±13.68),(75.17±10.13),(78.75±12.35),(70.01±22.07),(80.27±8.06).6th weeks:(95.67±3.65),(90.83±12.25),(96.13±3.93),(92.50±5.37),(92.50±5.98),(95.00±6.23),(88.90±15.97),(92.67±4.53),(P<0.05)].The results show that Escitalopram oxalate tablets,biofeedback cognitive behavioral therapy and vestibular rehabilitation,Duloxetine hydrochloride enteric capsule,biofeedback behavioral cognitive therapy and vestibular rehabilitation could improve the dizziness symptoms of patients with persistent postural perceptual dizziness,and could relieve patients’ anxiety,depression,so as to improve the quality of daily life.In the comprehensive treatment program,Duloxetine hydrochloride enteric capsule is more effective than Escitalopram oxalate tablets in the treatment of persistent postural perceptual dizziness. |
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