Studies On The Secondary Metabolites From The Mangrove Endophytic Fungus Aspergillus Sp.xy14

Mangrove forests grow in tropical and subtropical intertidal estuaries,which are a variety of salt-tolerant plants.Due to their unusual living enviroument,mangroves and the endophytic fungi are widely regarded as a treasure trove for producing of secondary metabolites with unique structures and biological activities.In this paper,the secondary metabolites of Aspergillus sp.xy14 have been investigated.As a result,twenty-seven compounds were isolated and identified by UV spectrum,Optical rotation spectrum,LR/HR-ESI-MS,and extensive NMR investigations.The twenty-seven compounds identified including four meroterpenoids:asperterpenes P(1),terretonin A(2),terretonin(3),and terretonin D(4);six butyrolactones:butyrolactone I(5),butyrolactone V(6),butyrolactone II(7),aspernolide D(8),aspernolide B(9),and aspernolide A(10);four monacolins:lovastatin(11),monacolin L(12),lactone ring-opened monacolin K(13),and lactone ring-opened monacolin L(14);thirteen other compounds:(+)-terrein(15),(-)-orthosporin(16),(S)-3-((3,3-dimethyloxiran-2-yl)methyl)-4-hydroxybenzaldehyde(17),3,5-dihydroxytoluene(18),p-Hydroxybenzaldehyde(19),cis-4,6-dihydroxymellein(20),4-Hydroxy-3-(3-methyl-2-buten-1-yl)benzaldehyde(21),methyl 2,4-dihydroxy-3,5,6-trimethylbenzoate(22),2-hydroxy-5-oxo-3-((E)-prop-1-en-1-yl)cyclopent-3-en-1-yl acetate(23),asperterreusine C(24),1 H-indole-3-carboxaldehyde(25),orsellinaldehyde(26),and 6-hydroxymellein(27).Among them,compound 1 is a new compound and 17,23 were isolated from natural resource for the first time.Compound 2-13 was selected for inhibitory activity of α-glucosidase,acetylcholinesterase,and butyrylcholinesterase.The results showed that the inhibitory activity of compound 5 on α-glucosidase was stronger than the positive drug acarbose.