Obstructive Sleep Apnea And Clinical Outcomes Of Atrial Fibrillation

Objective:To analyze our data and explore the impact of obstructive sleep apnea on the prognosis of patients with AF and discover the risk factors that influence the prognosis of AF.Methods:Tocollect the AF patients who attended the People’s Hospital of Xinjiang Uygur Autonomous Region from January 1,2016 to December 31,2019,and to make the AF patients who completed sleep respiratory monitoring in the hospital into the our study group.To divide the study group into the AF with obstructive sleep apnoea and the AF withoutobstructive sleep apnoea and to collect the basic data of each subjectand the occurrence of end-point events,including systemic circulation embolism,heart failure,and cardiovascular death.To usethe SPSS statistical package toanalyse our data.Results:At the end of the study,a total of 120 patients were enrolled,of which 59 were in the atrial fibrillation and obstructive sleep apnea group and 61 were in the atrial fibrillation and obstructive sleep apnea group;Analysis of the baseline data showed a statistically significant difference(P<0.05)between the two groups in the alcohol consumption,Body Mass Index(BMI),(Apnea-Hypopnea Index)AHI,mean Oxygen saturation(Sa O2),minimum Sa O2,proportion with Sa O2 below 90%,and CHA2DS2-VASC score.After the end of follow-up,17 patients had heart failure or death.Kaplan-Meier survival analysis showed that there was significant difference between the two groups(P=0.006);10patients had systemic embolism,and the difference between the two groups was statistically significant(P=0.036).Severe OSA was associated with a significantly increased risk of heart failure or death from AF compared with mild OSA(P=0.003).Single and multiple Cox regression modelsanalyses identified LAVI(HR 1.36395% CI 1.037-1.793,P=0.027),AHI(HR 2.746 95% CI 1.252-6.027,P=0.012),proportion of oxygen saturation below 90%(HR 0.618 95% CI 0.431-.885,P=0.009)as independent risk factors for incident heart failure or death in patients with AF;AHI(HR1.098 95% CI 1.003-1.203 P=0.044),CHA2DS2-VASC score(HR3.895 95% CI1.305-11.623 P=0.015)were independent risk factors for the development of systemic embolism in AF.Conclusions: OSA increases the risk of heart failure or death and systemic embolism in patients with AF,and it is an independent risk factor influencing the prognosis of AF.