Comparison Of Modified Glasgow Prognostic Score And High-sensitivity Modified Glasgow Prognostic Score On The Prognostic Predict Of Patients With Colorectal Cancer

Objective: To investigate the value difference of modified glasgow prognostic score(mGPS)and high-sensitivity modified glasgow prognostic score(HS-mGPS)on the prognostic predict of patients with resectable colorectal cancer(CRC).Methods:The clinical data of 307 CRC patients who underwent curative resection between January 2010 and December 2013 at the central hospital of Panzhihua City were respectively collected.And all the patients were scored according to the score criterion of HS-mGPS and mGPS before surgery.Compare the difference of clinicopathological characteristics of tumors and prognostic between patients with different scores.Results: Among 307 patients with CRC,preoperative mGPS scores were 227 in mGPS 0,46 in mGPS 1 and 34 in mGPS 2.An increased mGPS was significantly associated with older age(p=0.003),a more advanced TNM stage(p=0.000),and lymphatic invasion(p=0.025).In contrast,Before surgery,146 patientshad HS-mGPS of 0,101 patients had HS-mGPS of 1,and 60 patients had HS-mGPS of 2.An increased HS-mGPS score was also associated with older age(p=0.000),a more advanced TNM stage(p=0.000)and lymphatic invasio n(p=0.039).Univariate analysis identified that age(P<0.001),T stage(P<0.001),N stage(P<0.001),histology(P<0.001),lymphatic invasion(P<0.001),vascular invasion(P<0.001),mGPS(P=0.002)and HS-mGPS(P<0.001).were potentially prognostic factorsfor overall survival.By multivariate analysis,age(P<0.001),T stage(P<0.001),N stage(P<0.001),histology stage(P=0.034),lymphatic invasion(P<0.001)and HSmGPS(P<0.001)were found to be significantly associated with overall survival.Compared with mGPS,the HS-mGPS was proved to be a superior prognostic predictor(P < 0.001).Conclusion:These results suggest that the preoperative HS-mGPS might have agreater prognostic impact than the mGPS in patients with resectable colorectal cancer.