| Objective: to observe the clinical efficacy and safety of Jiawei Sanren decoction combined with Kangfuxin liquid in the treatment of acne with damp-heat accumulation syndrome.Methods: A total of 108 patients who met the inclusion criteria were randomly divided into treatment group(oral Jiawei Sanren decoction combined with Kangfuxin liquid wet application),control group Ⅰ(oral doxycycline hydrochloride capsule combined with Kangfuxin liquid wet application)and control group Ⅱ(external application of Kangfuxin liquid).In addition,patients in the three groups were treated with acne ointment,plaster and red and blue light once a week.2 weeks as a course of treatment,continuous treatment for 3 courses,before treatment,treatment for 2 weeks,treatment for 4 weeks and treatment for 6 weeks,the skin lesion score,secondary disease score,comprehensive curative effect score and adverse reactions were recorded,and the curative effect was judged.After treatment,the patients were followed up for 2 months,the recurrence was counted,and the data of the three groups were recorded into SPSS26.0 for statistical analysis.Results:1.Among the 108 patients included in the study fall off 5 cases,the actual number of cases was 103,total shedding rate was 4.63%.there was no significant difference in the general data of the three groups before treatment(P> 0.05).2.After treatment,compared with the clinical efficacy of the three groups,the total effective rate of the treatment group was 91.4%,the total effective rate of control group Ⅰwas 73.5%,and the total effective rate of control group Ⅱ was 67.6%.The results show that the three treatments are effective in the treatment of acne.The curative effect of the treatment group was better than that of the control group Ⅰ and control group Ⅱ(P< 0.05),but there was no significant difference between the control group Ⅰ and the control groupⅡ(P> 0.05).3.After treatment,the score of skin lesions in the three groups decreased to a certain extent compared with that before treatment,and the difference was statistically significant(P< 0.05).After 2 weeks treatment,the score of skin lesions in control group Ⅰwas lower than that of treatment group and control group Ⅱ,and the score of treatment group was lower than that of control group Ⅱ(P< 0.05).After 4 weeks treatment,the score of skin lesions in the treatment group was slightly lower than that in the control group Ⅰ,but there was no significant difference(P> 0.05).The score of skin lesions in the treatment group and the controlgroup Ⅰ was lower than that in the control group Ⅱ,and the difference was statistically significant(P< 0.05).After 6 weeks of treatment,the score of treatment group was lower than that of control group Ⅰ and control group Ⅱ,and the score of control group Ⅰ was lower than that of control group Ⅱ,the difference was statistically significant(P< 0.05).4.After treatment,the scores of secondary symptoms in the three groups decreased in varying degrees compared with those before treatment,and the differences were statistically significant(P < 0.05).After 4 weeks and 6 weeks of treatment,the scores of secondary symptoms in the treatment group were lower than those in the control group Ⅰand control group Ⅱ,and the differences were statistically significant(P< 0.05).Compared with control group Ⅱ,the symptom score of control group Ⅰ was lower than that of control group Ⅱ after 2 weeks,4 weeks and 6 weeks of treatment,but the difference was not statistically significant(P > 0.05).5.After treatment,the comprehensive curative effect scores of the three groups decreased in varying degrees compared with those before treatment,and the differences were statistically significant(P< 0.05).Compared between the two groups,there was no significant difference between the treatment group and the control group Ⅰ after 2 weeks and 4 weeks of treatment(P> 0.05).After 6 weeks of treatment,the score of the treatment group was lower than that of the control group Ⅰ,and the difference was statistically significant(P< 0.05).The score of treatment group and control group Ⅰ was lower than that of control group Ⅱ,and the difference was statistically significant(P< 0.05).6.After treatment,the(DLQI)score of skin quality of life index in the three groups decreased to a certain extent,compared with that before treatment,the difference was statistically significant(P< 0.05).Compared between the two groups,the score of the treatment group was significantly lower than that of the control group Ⅰ and control groupⅡ(P< 0.05).The score of the control group Ⅰ was lower than that of the control group Ⅱ,and the difference was statistically significant(P< 0.05).7.In the comparison of adverse reactions among the three groups,there were no serious adverse reactions in the three groups,no adverse reactions in control group Ⅱ,mild adverse reactions in 4 patients in treatment group and 6 patients in control group Ⅰ,which were improved after symptomatic treatment.There was significant difference between the two groups(P< 0.05).Conclusion: oral Jiawei Sanren decoction combined with Kangfuxin liquid is effective,safe and reliable in the treatment of acne with damp-heat accumulation syndrome.Oral Jiawei Sanren decoction can mainly improve the systemic symptoms of patients,and external application of Kangfuxin liquid can reduce local inflammatory reaction.reduce the severity of skin lesions,prevent and reduce scar and pigmentation,the combination of the two,complementary advantages.It can effectively reduce the severity of acne patients and reduce the number of skin lesions,at the same time,improve the systemic symptoms of patients,so as to improve the quality of life of patients. |
PDF Full Text Request