| Purpose:This study was to observe the ECG curative effect,blood lipid level,vascular endothelium-dependent dilation(FMD),and Seattle Angina Pectoris Scale before and after treatment with Xintongning Recipe for patients with angina pectoris of Qi deficiency and blood stasis type after PCI.SAQ),TCM syndrome points,TCM syndrome efficacy and other indicators,To evaluate the efficacy and safety of Xintongfang in the treatment of angina pectoris in patients with Qi deficiency and blood stasis after PCI of coronary heart disease,and to provide a reference for recurrence of angina pectoris after PCI of coronary heart disease.Methods: From April 2020 to January 2021,60 patients who were hospitalized in the Department of Cardiovascular Medicine,First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine were selected to be clearly diagnosed as coronary heart disease after PCI and recurring angina pectoris.The TCM syndrome classification was Qi deficiency and blood stasis type.The patient is the research object.According to the random number table method,the study subjects were divided into treatment group and control group,each with 30 cases.Among them,the control group is the standardized treatment of western medicine,which is taken for a long time.(Aspirin enteric-coated tablets,once a day,100 mg each time,orally;Clopidogrel bisulfate tablets,once a day,75 mg each time,orally,atorvastatin calcium tablets: once a night,20 mg each time,orally;Metoprolol succinate sustained-release tablets: 1 time a day,11.875 mg per day～47.5mg,orally;isosorbide mononitrate sustained-release tablets: once a day,40 mg each time,orally).On the basis of the control group,the treatment group was added with Xintongning prescription Chinese medicine,2 times/day,1bag/time,warmed up in the morning and evening after meals,the course of treatment was 4 weeks,and the changes in the electrocardiogram before and after treatment(ST-T segment changes)were recorded.The blood lipid level,FMD,SAQ,TCM syndrome score,TCM syndrome curative effect,etc.,and analyze it.Results:(1)SAQ: Comparison of physical activity limitation,stable angina pectoris,angina pectoris,treatment satisfaction,and disease cognition of the two groups before treatment.P>0.05,which is comparable.After treatment,The improvement of angina pectoris stability,angina pectoris episodes,treatment satisfaction,and disease awareness of the treatment group was better than that of the control group(P<0.05),but the improvement in the degree of physical activity limitation of the two groups was equivalent(P >0.05).(2)Blood lipid level: After treatment,the blood lipid indexes of the two groups of patients were lower than before treatment,and the reduction degree of the treatment group was higher than that of the control group.The comparison of density lipoprotein cholesterol(LDL-C)index levels(P<0.05)was statistically significant,and the reduction of TG and LDL-C levels in the treatment group was better than that in the control group.However,the comparison of serum total cholesterol(TC)indexes between the two groups of patients was not statistically significant(P>0.05),indicating that the TC levels of the two groups of patients did not improve significantly before and after treatment.(3)ECG curative effect: After treatment,the effective rate of improving ECG curative effect of the treatment group and the control group was 66.66%and 53,33% respectively,P>0.05,indicating that after treatment,through the comparison of the ECG curative effect of the two groups of patients,The ECG curative effect of the two groups of patients was similar.(4)FMD: By comparing the results of the study,the endothelium-d ependent diastolic function(FMD)level of the two groups of patients was higher than that before treatment(P<0.05),and the up-regulated F MD level of the treatment group was higher than that of the control gr oup.FMD level(P<0.05).(5)TCM syndrome score: After treatment,the TCM syndrome scores of the two groups of patients were lower than before treatment(P<0.01),there was a significant difference,and the improvement of TCM symptoms of the treatment group was better than that of the control group.The degree of improvement of TCM symptoms.(6)The curative effect of TCM symptom: The curative effect of TCM symptom of the two groups of patients after treatment has been improved to a certain extent,and the total effective rate of the treatment group is 93.33%higher than that of the control group 66%,and the difference is statistically significant(P<0.05)).Conclusion:(1)Xintongning Decoction can effectively reduce the onset of angina pectoris after PCI in patients with coronary heart disease of deficiency of qi and blood stasis,improve the endothelial function of the brachial artery,and improve the quality of life of the patients.Xintongning Decoction provides effective data for the treatment of angina pectoris after PCI of coronary heart disease,and no obvious adverse reactions have been seen.Its clinical application safety is relatively high.(2)Xintongning Decoction can effectively improve the curative effect of TCM symptoms.Xintongning Decoction combined with conventional Western medicine treats symptoms such as chest tightness,chest pain,palpitations,fatigue,shortness of breath,and dark lips in patients with angina pectoris(qi deficiency and blood stasis type)after coronary heart disease PCI.The improvement has obvious advantages,and the safety is good.(3)The mechanism of Xintongning Decoction in treating angina pectoris after PCI of coronary heart disease is related to improving brachial artery endothelial function,controlling blood lipid levels,and reducing the number of angina pectoris after PCI. |
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