| Purpose:To observe the changes of the macula and optic disc in both eyes of patients with retinal vein occlusion(RVO)using optical coherence tomography(OCTA).Analyzing quantitatively those changes include the superficial capillary blood flow density(SVD),the deep capillary blood flow density(DVD)and morphological the changes of the foveal avascular zone(FAZ)of the macular area and the peripapillary vessel density(pVD)and the thickness of the peripapillary nerve fiber layer(pRNFL)in the optic disc area to initially determine the monitoring indicators for fundus lesions in the contralateral eye and high-risk groups.Methods:Retrospective,case-control study.This study collected clinical data of 43 patients diagnosed with unilateral RVO in the Department of Ophthalmology of the First Affiliated Hospital of Anhui University of Science and Technology from January to December 2020.There were 86 eyes in total.Taking 43 RVO eyes as the affected side group,follow healthy eyes were used as the follow group.In the control group,staff or family members of the hospital were selected as healthy volunteers,with a total of 21 people and 42 eyes matching their age and sex with RVO.Using OCTA instrument scaned the macular and optic disc area to observe the changes of SVD and DVD values in three groups within 1mm of the macular center,nasal(N),temporal(T),superior(S),and inferior(I)regions of the macula and measured FAZ area,perimeter and perimeter index(AI).It was also observed the changes of blood flow in inside of optic disc and the changes of pVD and pRNFL in 8 areas of peripapillary optic disc include superior temporal(TS),superior temporal(ST),superior nasal(SN),superior nasal(NS),nasal inferior(NI),inferior nasal(IN),inferior temporal(IT),and inferior temporal(TI).Analyzed by ANOVA,Mann-Whitney U test and canonical correlation analysis performed comparison difference.P<0.05 represents statistically significant difference.Results:43 unilateral RVO patients.including 25 males and 18 females,13 CRVO patients and 30 BRVO patients;aged 30-74 years old,with an average age of 55.49±10.01 years old were observed in this study.A total of 21 healthy volunteers and 42 eyes were enrolled,including 10 males and 11 females,aged 46-59 years old,with an average age of 53.24±4.45 years old.There was no significant difference in age(t=1.344,P=0.184)and sex ratio(χ2=0.19,P=0.663)between the two groups of subjects(P>0.05).The results of OCTA examination showed that the SVD within 1 mm of the macular heart among the three groups decreased,and the SVD and DVD of the S,N,T and I quadrants decreased.These changes were statistically different(P<0.01).The area(P=0.455)and circumference(P=0.959)of FAZ among the three groups did not increase significantly,but there were significant statistical differences in the VD in the AI and FD-300 regions(P<0.0001).Compared with the control group,the DVD of the T,S,N and I side quadrants of the macular area of the follow eye decreased,which was statistically different(P<0.05).There were statistically significant differences in VD between the three groups in inside disk,overall and peripapillary superior(pS),ST,and SN(P<0.01),but there wre no statistical difference of pVD in peripapillary inferior(pI),NS,NI,IN,IT,TI and TS(P>0.05).Compared with the control group,the pVD in each area of the follow eye was reduced,and the VD in the disc of the follow eye decreased most significantly(P=0.011).There were statistical differences in the thickness of pRNFL in the regions of NI,IT,TI,TS,and ST among the three groups(P<0.05).There was no statistical difference in the thickness of pRNFL in the whole disc,pS,pI,NS,IN and SN regions(P>0.05).The thickness of pRNFL in the ST and IT regions around the disc was lower than that in the control group(P=0.001).Pearson correlation analysis showed that the average pVD and pRNFL thickness of the affected side group and the follow group were positively correlated,and the correlation was not strong(r=0.0978,P=0.5326;r=0.1235,P=0.4301).But the two were negative in the control group,which was relatively low(r=-0.1812,P=0.2507).The typical correlation analysis showed that pVD and pRNFL thickness comprehensive variable sets have a strong positive correlation(P<0.001).Conclusions:OCTA can fully quantify the changes in the blood flow and structure of the macula and optic disc of patients with RVO.The reduced VD of the RVO eye can be used to evaluate the severity of the RVO eye.As an observation index for diagnosis and treatment,pVD has a strong correlation with the thickness of pRNFL,and decreased blood perfusion can damage the optic nerve.While diagnosing and treating the affected eye,we should pay more attention to the changes in the follow eye,especially the changes in the thickness of the DVD in the macular area,the intradiscal VD,the ST and IT regions of the disc.Using those as observation indicators for monitoring the contralateral eye and high-risk groups can provide a scientific reference for the prevention of eye disease.Figure 17 table 11 reference 51... |
PDF Full Text Request