| Objective: This topic aims to evaluate whether Jianpi Huashi Decoction has advantages in the treatment of diarrhea-type irritable bowel syndrome(IBS-D)with spleen deficiency and dampness syndrome,and to promote the clinical practice of diarrhea-type irritable bowel syndrome(spleen deficiency and dampness syndrome)Provide the basis in the application.Methods: Sixty-two cases of IBS-D patients with spleen deficiency and dampness that met the inclusion criteria were randomly divided into the treatment group and the control group with 31 cases each using a random number table.During the treatment,2 cases in the treatment group fell off,and 1 case in the control group fell off.Control group: Pinaverium bromide tablets(Desutte)50 mg,3 times a day,1 tablet each time,swallowed with three meals,and taken for 1 month.The treatment group was given Jianpi Huashi Decoction,1 dose a day,mixed with warm water,divided into morning and dinner,and the treatment time was 1 month.The two groups were treated for 4 weeks.Before and after treatment,the total scores of TCM symptoms,the scores of individual symptoms of TCM,the severity of IBS symptoms(IBS-SSS),and the irritable bowel syndrome quality of life scale score(IBS-QOL),serum 5-HT,VIP levels and adverse reactions were observed.The two groups were followed up within 1 month after the end of the medication.The difference in points before and after treatment was compared to evaluate the effect of Jianpi Huashi Decoction on IBS-D spleen deficiency and dampness The clinical efficacy of Shengzheng.Results:1.Overall curative effect analysis: After 4 weeks of treatment,7 persons in the treatment group recovered,13 persons were effective,6 persons were effective,and 3 persons were ineffective.The total effective rate was 89.66%;in the control group,3 persons were cured,8 persons were markedly effective,and 12 persons were effective.7 people were ineffective,and the total effective rate was 76.67%,which was statistically significant between the two groups(P<0.05).2.Individual symptom score: After 4 weeks of treatment,the treatment group and the control group have significantly improved the main symptoms(diarrhea,abdominal pain,defecation traits)and secondary symptoms(fatigue,drowsiness,fear of food,coldness,and appetite)compared with before treatment.All are statistically significant(P<0.01);comparison between groups after treatment: the treatment group and the control group have no significant difference in improving the main symptoms of abdominal pain(P>0.05),and the other symptom treatment group is better than the control group(P<0.05)).3.Severity of IBS-SSS symptoms: P<0.01 in comparison of IBS-SSS scores in each group after treatment,indicating that there are significant differences in IBS-SSS scores before and after treatment in each group;at the same time,the IBS-SSS scores of the two groups of patients after treatment The comparison P<0.05 indicates that the treatment group is better than the control group in improving the severity of IBS-D.4.IBS-QOL quality of life score: Compared within the group after treatment,there was no significant difference between the two groups in terms of improving social attention and sexual behavior from before treatment(P>0.05),and the scores of other dimensions were better than those before treatment(P<0.05),the treatment group is better than the control group in four dimensions: emotional anxiety,physical intention,health concern,and diet concern(P<0.05).Among them,anxiety and physical intention are particularly obvious(P<0.01).5.Analysis of plasma 5-HT and VIP levels: After the course of treatment,the plasma 5-HT and VIP levels of the two groups of patients decreased compared with the previous,and the treatment group was down-regulated by a greater degree than the control group(P<0.05).6.Recurrence rate and safety analysis: 4 out of 26 people in the treatment group relapsed,with a recurrence rate of 15.38%,and 10 out of 23 people in the control group who were followed up,with a recurrence rate of 43.48%.The recurrence rate was significantly lower than that of the control group(P<0.05).Within 1 month from the beginning of the treatment to the end of the course of treatment,the patients in each group who had achieved significant effects in TCM syndromes were followed up without serious adverse reactions,and no obvious abnormalities in the vital signs and auxiliary examinations.Conclusion:Jianpi Huashi Decoction has the effects of invigorating the spleen,dissipating dampness and regulating qi.It has a definite curative effect on the treatment of spleen deficiency and dampness type IBS-D.Its overall effect is better than pinaverium bromide tablets,and it can effectively improve diarrhea,defecation traits,and fear of food.Coldness,fatigue,drowsiness,anorexia and other symptoms;it can reduce the severity of symptoms,reduce plasma 5-HT and VIP levels,improve the quality of life,and has a good short-term curative effect,which is worthy of clinical promotion. |
PDF Full Text Request