Pulmonary Infection Prevention Research Of Using Modified Xinglou Chengqi Decoction To Treat Acute Stroke Of Phlegm-heat And Sthenic-fu Type

Objective: To explore the preventive actions of Supplemented Xinglou Chengqi Decoction on stroke-associated pneumonia(SAP),so as to provide new idea to clinical prevention of the occurrence of SAP.Methods: A total of 60 patients who diagnosed with Heat-phlegm and Sthenic-fu Type of acute ischemic stroke were selected.60 patients who were randomly divided into treatment group and control group,with 30 cases in each group.The two groups both were given western comprehensive treatment.Treatment group received oral or nasal feeding Supplemented Xinglou Chengqi Decoction on the basis of the western comprehensive treatment.On the basis of the western comprehensive treatment control group received suppositories glycerol and(or)Duphalac if necessary.Observations were stopped in the treatment of 1 week or SAP diagnosed.Evaluating related indicators of the two groups.Results:1.Analysis of general information of treatment group and control group:There was no statistical significance in age,gender,basic diseases,risk factors between the two groups(P > 0.05).There was no statistical significance in NIHSS score,TCM syndrome score,WBC count.And the general information of two groups is comparable.2.Analysis of total clinical efficacy of treatment group and control group: The incidence of SAP of treatment group is 10%,and 36.7% in the control group,and the results of two groups compared had a statistical significance(P <0.05).In terms of total efficacy of TCM,the total effective rate of the treatment group was 96.7%.The total effective rate of the control group was 66.7%,and the difference was statistically significant(P<0.05).3.Analysis of NIHSS score: after treatment,there was no statistical significance in NIHSS scores between the two groups(P>0.05),there was statistical significance in NIHSS scores before treatment and after treatment in the inter-group(P<0.05).4.Analysis of TCM syndrome score: after treatment,there was statistical significance in TCM syndrome score between the two groups(P>0.05).5.Analysis of WBC count : after treatment,there was statistical significance in WBC count between the two groups(P>0.05).6.Safety evaluation: Before treatment and after treatment,no abnormal changes were observed in routine urine test,routine stool test,liver function,renal function,electrolytes,electrocardiogram.There were 2 cases of diarrhea in the treatment group,may caused by the impact of Chinese medicine.When adjust the dosage of Chinese medicine,symptoms of diarrhoea disappeared,no other special treatment was give,the drug safety was judged as Ⅱ.There were no obvious adverse reactions in the other patients.There was no statistically significance difference between the two groups in the cases of adverse reactions(P>0.05).Conclusions:1.Adding Supplemented Xinglou Chengqi Decoction on the basis of the western comprehensive treatment,founded that Supplemented Xinglou Chengqi Decoction can reduce the incidence of SAP,improve the TCM syndrome performance of patient,decreased NIHSS score for acute ischemic stroke,make WBC count to be better,improve clinical efficacy.2.Supplemented Xinglou Chengqi Decoction is safe and effective,worthy of promotion.