Observation On The Clinical Effect Of Shuyi Powder In Treating Adolescents With Mild To Moderate Depression

Objective: To evaluate the clinical efficacy and safety of Shuyi powder in the treatment of mild and moderate depression(deficiency of liver and soul and depression of spleen)in adolescents.Method: A total of 60 adolescent patients with mild and moderate depression who met the inclusion criteria were randomly divided into two groups: the experimental group(Shuyi powder group)and the control group(Sertraline hydrochloride group),with 30 cases in each group.The treatment course was 8 weeks.The Hamilton Depression Scale(HAMD-24)and TCM syndrome scoring scale were used to evaluate the clinical efficacy,adverse reactions and safety of the two groups.Results: The effective rates of HAMD scale in the experimental group and the control group were 93.99% and 83.33%,respectively,and the effective rates of TCM syndrome were 90.00% and 76.67%,respectively.The efficacy of the experimental group was better than that of the control group(P<0.05).After 2 weeks,4 weeks and 8 weeks of treatment,HAMD score and TCM syndrome score decreased in both groups,and the differences were statistically significant after 8 weeks of treatment(P < 0.05).The symptoms of anxiety/somatization,cognitive disorder,sleep disorder factor,depression,sleeplessness and dreaminess were significantly improved in experimental group.The incidence of adverse reactions in the test group was lower than that in the control group,and the safety was good.Conclusion: Shuyi powder is safe and effective in the treatment of adolescents with mild and moderate depression,and the incidence of adverse reactions is low.