Clinical Observation Of Tongxie Yaofang And Wuling Powder In The Treatment Of IBS-D With Stagnation Of Liver And Deficiency Of Spleen

ObjectiveTo observe and evaluate the clinical efficacy of Tongxie Yaofang and Wuling Powder in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D)with stagnation of liver and deficiency of spleen,and to provide clinical evidence for its promotion and application.Methods80 cases of IBS-D patients with liver depression and spleen deficiency were divided into two groups by random number table method,with 40 cases in each group.The Chinese medicine group was given Tongxie Yaofang and Wuling Powder,and the control group was given compound Lactobacillus acidophilus.Both groups were treated for 4 weeks.Irritable bowel syndrome symptomatic severity scale(IBS-SSS),diarrheal disease(diarrhea-predominant irritable bowel syndrome)doctor-reported outcome scale and traditional Chinese medicine(TCM)syndrome rating scale were used before and after treatment to evaluate patients’ conditions.According to the total score of TCM syndrome rating scale before and after treatment,the number of cured,evidently effective,effective,invalid patients and total effective rate in each group were calculated.Adverse reactions were observed during treatment.Follow-up was conducted 1 month after the end of treatment to determine the recurrence rate.Results1.There was no significant difference in the total score of IBS-SSS between the two groups before treatment(P>0.05).After treatment,the total scores of both groups were lower than those before treatment,and the differences were statistically significant(P<0.01).After treatment,the total score and total score difference of Chinese medicine group were significantly different from those of control group(P<0.01).Both treatments can reduce the total score of symptom severity scale of irritable bowel syndrome,and the effect of Chinese medicine group is better than that of control group.2.There was no significant difference in the total score of diarrheal disease(diarrhea-predominant irritable bowel syndrome)doctor-reported outcome scale between the two groups before treatment(P>0.05).After treatment,the total scores of both groups were lower than those before treatment,and the differences were statistically significant(P<0.01).After treatment,the total score and total score difference of Chinese medicine group were significantly different from those of control group(P<0.01).It is suggested that both treatments can reduce the total score of diarrhoeal disease(diarrhea-predominant irritable bowel syndrome)doctor-reported outcome scale,and the effect of the Chinese medicine group is better than the control group.3.There was no significant difference between the two groups in the total scores of TCM syndrome rating scale before treatment(P>0.05).After treatment,the total scores of both groups were lower than those before treatment,and the differences were statistically significant(P<0.01).After treatment,the total score and total score difference of Chinese medicine group were significantly different from those of control group(P<0.01).Both treatments could reduce the total scores of TCM syndrome rating scale,and the effect of Chinese medicine group was better than that of control group.4.After treatment,3 patients in the Chinese medicine group were cured,12 patients were evidently effective,14 patients were effective and 11 were invalid.In the control group,none of the patients were cured,1 patient was evidently effective,12 patients were effective,and 27 patients were invalid.The differences were statistically significant(P<0.01).It is suggested that the curative effect in the Chinese medicine group was better than that in the control group.The total effective rate of Chinese medicine group was 72.50%,and that of control group was 32.50%.The total effective rate of Chinese medicine group was significantly better than that of control group(P<0.01).5.No adverse reactions occurred in the two groups during the treatment.6.In the follow-up,the recurrence rate of the Chinese medicine group was 13.80%,and that of the control group was 15.38%.There was no statistical significance in the recurrence rate between the two groups(P>0.05).ConclusionCompared with compound Lactobacillus acidophilus in the treatment of IBS-D patients with depression of liver and deficiency of spleen,Tongxie Yaofang and Wuling Powder can more effectively reduce the total score of IBS-SSS,diarrhoeal disease(diarrhea-predominant irritable bowel syndrome)doctor’s reported outcome scale and TCM syndrome rating scale.It has better curative effect,higher effective rate,and is worthy of clinical promotion.