Clinical Study On The Treatment Of Primary Dysmenorrhea Of Cold Coagulation And Blood Stasis Type By Moxibustion

Objective:To observe the clinical effect of moxibustion on primary dysmenorrhea of cold coagulation and stasis type,and to provide the optimized treatment plan for the clinical treatment of primary dysmenorrhea of cold coagulation and stasis type.Methods:98 patients with primary dysmenorrhea of cold coagulation and stasis type were randomly divided into two groups:drug separated moxibustion group（49 cases）and Western medicine group（49 cases）.The moxibustion group was treated with moxibustion 3 days before menstruation,while the western medicine group took ibuprofen sustained-release capsule when menstrual pain.Two groups were treated for three days,one menstrual cycle was one course,and two groups were treated for three courses.The visual analog scale（VAS）and the Cox menstrual symptom scale of pain and the serum were used before treatment,the first,the second,the third course of treatment and the five points of follow-up,The content of PGE₂ and PGF_2αbefore and after treatment was used as the observation index to evaluate the therapeutic effect of moxibustion on primary dysmenorrhea of cold coagulation and stasis type.Results:1.VAS score:Intra group comparison of different time points:At the first,second and third course of treatment,the VAS score of the two groups was significantly lower than that before treatment（P>0.05）.During the follow-up,the VAS score of moxibustion group was lower than that before treatment（P<0.05）,but there was no significant difference between western medicine group and that before treatment（P>0.05）.Comparison of different time points between groups:At the first course,the score of Western medicine group was lower than that of moxibustion group（P<0.05）,but there was no significant difference between the two groups in the second and third course（P>0.05）,and at the follow-up,the score of moxibustion group was lower than that of Western medicine group（P<0.05）.2.CMSS（duration,severity）score:Intra group comparison of different time points:In the first,second and third course of treatment,the scores of the two groups decreased significantly compared with that before treatment（P<0.05）.During the follow-up,the score of patients in the moxibustion group was lower than that before treatment（P<0.05）,but there was no significant difference between the western medicine group and that before treatment（P>0.05）.Comparison of different time points between groups:The scores of CMSS in the first,second and third course of treatment and follow-up in moxibustion group were lower than those in western medicine group（P<0.05）.3.PGE₂,PGF_2αThere were significant differences in PGE₂ and PGF_2αbetween the two groups before and after treatment（P<0.05）.After treatment,there was significant difference between the two groups（P<0.05）.Conclusions:1.Both medicine separated moxibustion and Western medicine can reduce VAS score.The recent analgesic effect of Western medicine is better than that of medicine separated moxibustion,and the long-term analgesic effect of medicine separated moxibustion is better than that of Western medicine.2.The therapeutic effect of moxibustion with medicine separation is better than that of Western medicine in relieving the duration and severity of other accompanying symptoms of dysmenorrhea.3.Western medicine and separated moxibustion can reduce the level of PGF_2αand improve the level of PGE₂ in patients with primary dysmenorrhea of cold coagulation and stasis type,but separated moxibustion can reduce the level of PGF_2αand improve the level of PGE₂ better than western medicine.