| Objective: To investigate the clinical efficacy of edaravone injection combined with butylphthalide injection in the treatment of acute ischemic stroke(AIS),and its effect on the serum levels of inflammatory factors and antioxidants in patients,so as to provide valuable references for clinicians.Methods: 104 patients with acute ischemic stroke admitted to our hospital from April 2019 to December 2019 were selected as the study subjects.The patients were divided into experimental group and control group by random number table or computer blind selection,with 52 cases in each group.The control group was treated with simple butylphthalide injection,and the experimental group was treated with edaravone injection and butylphthalide injection.On two groups of patients after treatment for 14 d of the clinical curative effect,nerve dysfunction score before and after the treatment ability score(NIHSS score)with daily life(ADL)change,before and after treatment serum hypersensitive c-reactive protein(hs-CRP)and superoxide dismutase(SOD)level change and the treatment of adverse reactions occurred during the observation and comparison.According to the obtained research results,SPSS21.0 software was used for analysis and comparison between groups to determine the therapeutic effect of edaravone injection combined with butylphthalide injection on acute ischemic stroke,so as to provide certain preparations for subsequent studies.Results: 1.After 14 d of drug treatment,the total effective rate of treatment of the experimental group was 96.15% and that of the control group was 84.62%.The total effective rate of the experimental group was significantly higher than that of the control group and the difference was statistically significant(x2=3.983,P < 0.05).2.Before treatment,NIHSS score of the experimental group was(22.26±1.56)while that of the control group was(22.08±1.52),without statistically significant difference(t=0.596,P > 0.05).Before treatment,ADL score of the experimental group was(50.26±4.56)points and that of the control group was(50.44±4.61)points without statistically significant difference(t=0.200,P > 0.05).NIHSS score of the treatment control group after 14 d was(7.25±0.86),which was significantly lower than that of the control group(11.26±1.21).The difference was statistically significant(t=19.479,P < 0.05).ADL score of the experimental group was(81.12±6.25),significantly higher than that of the control group(72.21±5.41)and the difference was statistically significant(t=7.773,P < 0.05).3.Before treatment,the serum SOD level of the experimental group was(162.25±14.52)U/L,while that of the control group was(161.89±14.26)U/L.There was no statistically significant difference between the groups(t=0.128,P > 0.05).Before treatment,the serum hs-crp level of the experimental group was(16.56±2.41)pg/ml,while that of the control group was(16.42±2.38)pg/ml.There was no statistically significant difference between the groups(t=0.298,P > 0.05).After 14 days of symptomatic treatment,the serum SOD of the experimental group was(388.25±29.56)U/L,and that of the control group was(302.21±25.41)U/L.The difference between the groups was statistically significant(t=15.917,P < 0.05).After treatment,the serum hs-crp of the experimental group was(8.33±1.46)pg/ml,while that of the control group was(10.56±1.75)pg/ml.The difference between the groups was statistically significant(t=7.056,P < 0.05).4.During symptomatic treatment,4 cases of adverse reactions occurred in the experimental group,with a total incidence of 7.69%.During treatment,5 cases of adverse reactions occurred in the control group,with a total incidence of 9.62%.There was no statistically significant difference in the total incidence of adverse reactions between the two groups(x2=0.122,P < 0.05).Conclusion: for the cerebrovascular disease,acute,ischemic cerebral stroke in clinical disease,using the adr in the combination of injection combined butyl phthalide injection solution than simply using butyl phthalide injection regimen of effect is good,the main combination treatment of total effective rate is higher,more effective improved nerve dysfunction,and improve the ability of daily life,and more significantly improve the level of serum SOD and lower serum hs CRP levels,no increase in adverse reactions occurred during medication. |
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