Meta-analysis Of Kuntai Capsules In The Treatment Of Decline Of Ovarian Reserve Function

Objective:To systematically evaluate the clinical efficacy of Kuntai capsule in the treatment of decreased ovarian reserve function,and to provide evidence-based basis for clinical practice.Methods:China National Knowledge Network（CNKI）,Wanfang Data Medical Information System（WF）,VIP Information Resource System（VIP）,Pub Med and Web of Science were searched.All literatures about Kuntai Capsule in the treatment of decreased ovarian reserve function were searched.The literatures were published from 2016 to February 2021.Note-express 3.2.0 literature manager was selected,and2 researchers independently screened and extracted literature information according to inclusion and exclusion criteria.The Cochrane bias risk assessment tool was used to evaluate the quality of the literatures that met the inclusion criteria.After the data were extracted and Meta-analysis was performed using Rev Man 5.3 software..Results:A total of 13 studies were included,all of which were randomized controlled studies（RCTs）,including 1224 patients.Meta-analysis results showed that:Compared with the control group,the levels of FSH[MD=-3.69,95%CI（-5.56,-1.81）,P=0.0001]and LH[MD=-1.18,95%CI（-1.86,-0.49）in the Kuntai capsule intervention group before and after treatment were significantly higher than those in the control group.P=0.0008],AFC[MD=0.93,95%CI（0.58,1.28）,P<0.00001],AMH level[MD=0.22,95%CI（0.10,0.34）,P=0.0002]The difference was statistically significant.There was no significant difference in E₂levels between the two groups[MD=3.62,95%CI（-2.81,10.06）,P=0.27]and FSH/LH levels[MD=-0.28,95%CI（-0.90,0.34）,P=0.38].Conclusion:Kuntai capsule can improve the decrease of ovarian reserve function by increasing the level of AMH,increasing the number of basal sinus follicles（AFC）,and decreasing the level of FSH and LH.However,there was no statistical significance in serum E₂levels and changes in FSH/LH levels.However,due to the limitation of the number and quality of the included studies,and the potential publication bias indicated by the data,the above conclusions need to be verified in more high-quality randomized clinical trials.