Correlation Between Aortic Valve Calcification And Coronary Heart Disease In North Henan

BackgroundThe prevalence and mortality of Coronary Heart Disease(CHD)are increasing year by year,and rural areas are higher than urban areas,which seriously threaten people’s life and health.Aortic valve calcification is a multi-factor,multi-mechanism,active-regulated pathological process that gradually aggravates with age.It is similar to CHD from epidemiology to histopathology.The status of aortic valve calcification and its correlation with the incidence and severity of coronary heart disease in rural areas in northern Henan remain unclear.ObjectiveTo investigate the correlation between Aortic Valve Calcification and Coronary Heart Disease in North Henan.MethodsFrom January 2016 to December 2018,a total of 2,089 patients in rural areas in northern Henan who underwent coronary angiography and echocardiography were selected from the Henan Provincial Cardiovascular Disease Clinical Data and Sample Resource Library Engineering Research Center.According to the results of coronary angiography,they were divided into 1454 persons in coronary heart disease group and 635 persons in non-coronary heart disease group.The detection rate of AVC between the two groups was compared,and the correlation between AVC and CHD was analyzed by binary logistic regression.Preference score matching(Propensity Score Match,PSM)eliminated the difference between groups and analyzed the effect of AVC on CHD incidence.According to different types of coronary heart disease(stable angina,unstable angina,acute myocardial infarction),the degree of coronary artery disease(mild,moderate,severe)and the number of diseased branches(single,double,and three)group analysis,there are Ordinal and Multivariate Logistic regression analysis of AVC and its correlation.Results1.Among the 2089 patients included in the study,CHD 69.6%(n = 1454),male57.2%(n = 1195),AVC 15.4%(n = 322),there are statistically significant differences in CHD group in gender,age,and differences in history of smoking,drinking,dyslipidemia,diabetes,hypertension,stroke,and aortic valve calcification comparing with non CHD patients(P < 0.05).The detection rate of AVC in the CHD group is significantly higher than that in the non-CHD group(269 18.5% vs.53 8.3%,P < 0.05).2.The regression analysis of Binary Logistic shows that AVC is positively correlated with the incidence of CHD in the population of northern Henan(OR 1.694,95% CI1.215-2.362).The propensity score matched to eliminate confounding factors such as sex,age,smoking,alcohol consumption,dyslipidemia,diabetes,hypertension,stroke,and so on.there was a statistically significant difference in aortic valve calcification between the CHD group and the non CHD group(P < 0.05).3.After the population is classified by gender,it is also an influencing factor of female CHD(OR 2.214,95% CI 1.379-3.557),and there is no correlation with the incidence of male population(P = 0.35).The proportion of smoking(6 1.1% vs.596 65.1%)and drinking(3 0.6% vs.320 35.0%)among female CHD patients in rural areas in northern Henan is lower than that of males,and the age of onset(62 years old)vs.60 years old)is older than men,a history of hypertension(338 62.7% vs.473 51.7%)and a history of diabetes(143 26.5% vs.176 19.2%)accounted for higher proportions than men.4.The regression analysis of Ordered Logistic showed that in addition to gender,age,dyslipidemia,history of diabetes,and history of stroke,AVC is an an influencing factor for the increase in the number of coronary lesions in patients with CHD in the region(OR1.330,95% CI 1.060-1.680).5.Multivariate Logistic regression analysis indicates that compared with the normal control group,patients with AVC are 2.037 times more likely to develop severe coronary artery disease than those without AVC(OR 2.037,95% CI 1.238-3.350),and people with AVC have no significant correlation with the incidence of mild and moderate coronary artery disease(OR 1.286,95% CI 0.799-2.069;OR 1.324,95% CI 0.803-2.184).Multivariate logistic regression analysis showed that compared with the non-CHD group,the probability of suffering from Stable Angina Pectoris in people with aortic valve calcification is 3.402 times that of people without aortic valve calcification(OR 3.402,95% CI 1.600-7.231),The probability of suffering from Unstable Angina is 1.749 times that of people without aortic valve calcification(OR 1.749,95% CI 1.185-2.582),and the probability of suffering from Acute Myocardial Infarction is 1.794 times that of people without aortic valve calcification(OR 1.794,95% CI 1.151-2.795).ConclusionAVC is the influencing factor for the total patients with CHD in northern Henan.The population in this area is AVC the influencing factor of female CHD disease,AVC there is no significant correlation to male CHD disease.Compared with those without AVC,patients with AVC have more coronary artery disease,the possibility of severe coronary disease is increased,and the probability of different types of coronary heart disease is increased.