| ObjectiveRecently with the application of transcatheter aortic valve replacement(TAVR),aortic valve calcification(AVC)has become one of the highlights in the cardiovascular field.The incidence of aortic valve lesions increases with age in patients with coronary heart disease,but there are few studies focusing on the occurrence of AVC in patients undergoing percutaneous coronary intervention(PCI)in the real world.The aim of this study was to elucidate the incidence and severity of AVC in patients undergoing PCI and to assess the association of AVC with coronary artery calcification(CAC)and risk factors for cardiovascular disease.MethodsThe clinical data of patients who underwent Coronary Computed Tomography Angiography(CCTA)examination and PCI in the General Hospital of Northern Theater Command from July 1 to October 1 2022 were collected,including demographic information,laboratory tests,echocardiography and coronary CT examination,PCI related data and medication during hospitalization.After CAC was analyzed using Intelli Space Portal workstation(Philips,the Netherlands),AVC was measured using3 mension software(Pie Medical Imaging,the Netherlands),and patients were divided into three groups according to the tertiles of CAC severity.The difference of AVC in each group was compared.The correlation between cardiovascular risk factors and AVC was statistically analyzed.ResultsA total of 211 patients were enrolled in this study.The average age of the patients was(60.1±8.3)years,and 149(70.6%)were male.There were 90(42.7%)cases of AVC and 200(94.8%)cases of CAC in the total population.Among the patients with CAC,90 patients(45%)had AVC.The mean age was(63.0±7.8),60(66.7%)were male,and CAC score [585.65(223.56,1544.53)vs.290.50(49.07,667.06),P< 0.001] was higher in patients with AVC than in those without AVC.There was a significant correlation between AVC and CAC(r Spearman=0.36,95% CI 0.23-0.48,P<0.001).There was a significant linear correlation between left main artery(LM)calcification and left coronary sinus calcification(r Spearman=0.25,95% CI 0.35-0.38,P<0.001).There was a linear correlation between Right coronary artery(RCA)calcification and right coronary sinus calcification(r Spearman=0.16,95% CI 0.12-0.38,P=0.012).Univariate Logistic regression analysis showed that,Age(OR 1.09,95% CI1.05~1.14,P<0.001),diabetes(OR 2.35,95%CI 1.26~4.44,P=0.007),CAC score(OR 1.00,95%CI 1.00~1.00,P<0.001)and antidiabetic drugs(OR 1.87,95%CI 0.63~5.87,P=0.005)were independent risk factors for aortic valve calcification.After adjusting for age,diabetes,CAC score,TG,and antidiabetic drugs,multivariate Logistic regression analysis showed that Age(OR 1.09,95%CI 1.05-1.14,P<0.001),CAC score(OR 1.00,95%CI 1.00-1.00,P<0.001),TG(OR 1.51,95%CI 1.00-1.00,P <0.001)1.15~2.15,P=0.002)were still the independent risk factors for aortic valve calcification.With the increase of the number of combined risk factors,AVC showed an upward trend.ConclusionsAVC occurs at a high rate in patients undergoing PCI and is significantly associated with CAC.The AVC score increased with age and the increase of cardiovascular risk factors.Calcification of the left main and right crown also predicts calcification of the corresponding valve leaflets. |
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