| Objective : By collecting medical records of patients with chronic hepatitis B in Professor Shi Chinese medicine studios and outpatient clinics,using data mining technology,explore the drug rule of Professor Shi in the treatment of chronic hepatitis B.Methods:Selected patients with chronic hepatitis B who were treated in Professor Shi Chinese medicine studios and outpatient clinics from February 2019 to December2020 and had complete data.According to the inclusion and exclusion criteria,746 cases were screened out,and the clinical case collection system and data processing were used.The system conducts statistics on medical records,analyzes and summarizes the results,and summarizes the academic thoughts and medication rules of Professor Shi in the treatment of chronic hepatitis B.Results:A total of 746 medical records were included in the study,and the following results were obtained:(1)463 male patients and 283 female patients,the ratio of male to female is about 5:3.(2)Most of the young and middle-aged patients are 31-60 years old.(3)The symptoms are fatigue,flank discomfort,poor appetite,mouth pain,abdominal distension,loose stools and so on.(4)The common TCM syndromes of chronic hepatitis B include single syndrome and compound syndrome.The single syndrome is divided into damp-heat internal syndrome,liver depression and spleen deficiency syndrome,qi and yin deficiency syndrome,blood stasis syndrome,and liver and kidney yin deficiency syndrome And spleen and kidney yang deficiency,among which damp-heat syndrome,liver depression and spleen deficiency syndrome are the most common,and deficiency of qi and yin is not uncommon.Complex syndromes are mostly syndromes of deficiency and excess,including damp-heat internal syndrome combined with liver stagnation and spleen deficiency syndrome,damp-heat internal syndrome combined with deficiency of qi and yin,and damp-heat internal syndrome combined with liver and kidney yin deficiency.Regardless of whether the patient has a single syndrome type or a compound syndrome type,both have different degrees of blood stasis and block the collaterals.(5)Clearing heat and eliminating dampness,promoting blood circulation and dredging collaterals,soothing liver and strengthening spleen,replenishing qi and nourishing yin,nourishing liver and kidney,warming spleen and kidney are commonly used treatment methods.(6)The traditional Chinese medicines commonly used by Professor Shi to treat chronic hepatitis B are Cyperus rotundus,Yujin,Yinchen,licorice,raw malt,Fushen,Coix seed,Eupatorium,Poria,Ligustrum lucidum,Scutellaria baicalensis,Taizishen,Chuanxiong,Agrimonia,White peony,Atractylodes,Gardenia,Habitat,Tangerine Peel,Zhejiang Fritillaria.(7)The meridian of the medicine is more common in the liver meridian,spleen meridian,lung meridian,stomach meridian,heart meridian and kidney meridian.(8)In the distribution of drug properties,cold,flat,and warm drugs are used more frequently;in the distribution of drug flavors,bitter,sweet and pungent drugs are used the most;in the drug classification,tonic drugs account for the largest proportion.(9)Commonly used drug combinations include Cyperus rotundus and Turmeric,Gardenia and Huoxiang,Taizishen and Ligustrum lucidum,Sea cuttlefish and Fritillaria,Inula and Madder,Lily and Habitat.(10)Chronic hepatitis B is actually a disease caused by Fuxie,which is a syndrome of deficiency and excess,the disease is located in the liver,and is closely related to the spleen,stomach and kidney.During treatment,the liver and spleen are treated at the same time,clearing heat and removing dampness,paying attention to treating both qi and blood,and protecting righteousness.Conclusion:1 Patients with chronic hepatitis B are more common in young and middle-aged men,which are in line with the clinical characteristics of chronic hepatitis B infection in China and adult onset;2 The clinical syndromes of chronic hepatitis B are often single syndrome and compound syndromes,while the complex syndromes are mostly syndromes of deficiency and excess.Blood stasis internal knots exist in different degrees in single syndrome type and compound syndrome type;3 In the treatment of chronic hepatitis B,clearing heat and removing dampness,promoting blood circulation and collaterals,nourishing yin and strengthening righteousness are more common.Therefore,using prescriptions,damp-heat yin injury,qi deficiency and blood stasis are often the main factors of chronic hepatitis B disease lingering and difficult to heal;4 From the point of view of the frequency and meridian use of Professor Shi’s treatment of chronic hepatitis B,in addition to clearing away heat and dampness,replenishing qi and nourishing yin,and dredging collaterals,there are also more drugs for soothing the liver,invigorating the spleen,and stomach.The professor sees the disease of the liver,knows that the liver transmits the spleen,and is the first to strengthen the spleen’s treatment philosophy;5 From the point of view of the nature and taste of the drug,the cold and warm temperatures are mixed,the bitterness and sweetness are too much,the pungent is bitter and the bitterness is reduced,and the sweetness can invigorate the spleen.This shows that Professor Shi pays more attention to the mutual perception of hepatitis B virus in the treatment of chronic hepatitis B,and takes care of Zhongzhou as the key.6 From the perspective of drug classification,there are many drugs for invigorating the deficiency and strengthening the body,indicating that Professor Shi’s treatment of chronic hepatitis B not only focuses on syndrome differentiation and treatment,but also combines the pathogenesis of chronic hepatitis B with the pathogenesis of positive deficiency and evil,and strengthens the body to drive away evil;7 From the perspective of commonly used drug pairs,Professor Shi often uses classic prescriptions to modify,which reflects his thoughts on the treatment of chronic hepatitis B;8 Chronic hepatitis B is a disease caused by Fuxie,which is a syndrome of deficiency and excess,and the disease is located in the liver,which is closely related to the spleen,stomach and kidney;9When Professor Shi treats chronic hepatitis B,he treats the liver and spleen simultaneously,clears heat and removes dampness,pays attention to regulating qi and blood,and always focuses on strengthening the body and eliminating evil,but focusing on strengthening the body and replenishing the deficiency. |
