| Purpose To study the clinical efficacy and clinical safety of the combination of Xingnao Zhitan Capsule and Xingnao Kaiqiao Acupuncture Method in the acute stage of stroke disease(cerebral infarction),and to investigate the mechanism of the action of Xingnao Zhitan Capsule and Xingnao Kaiqiao Acupuncture Method,so as to improve the recovery rate of disability and restore the daily living ability of stroke patients.MethodsThe cases in this study were obtained from patients admitted to the Department of Encephalopathy of Wuhu Chinese Medicine Hospital during June 2019-May 2020,with a total of 100 cases,using a randomized single-blind,experimental-controlled,balanced design scheme,with the corresponding random numbers generated from the collected cases according to the chronological order of consultation,and the cases were divided into 50 cases in the observation group and 50 cases in the control group with reference to the random numbers.In the control group,aspirin enteric dissolved tablets 100 mg and clopidogrel hydrogen sulfate 75 mg were given orally before breakfast once a day,and conventional treatments such as cerebral protection,lipid regulation and plaque stabilization,intracranial pressure lowering,blood pressure control and blood sugar control were given.In the observation group,on the basis of the treatment in the control group,the treatment was combined with Xingnao Zhitan Capsule and Xingnao Kaiqiao acupuncture method,and the duration of treatment was 14 days.The clinical efficacy was evaluated by observing the pre-and post-score changes of NIHSS score,BI index score,m RS scale and TCM symptomatology score,comparing the changes of blood routine,blood coagulation analysis,liver and kidney function,blood sugar and blood lipid,urine and stool routine and electrocardiogram before and after treatment,and recording the occurrence of various side effects during the treatment to evaluate the adverse reactions of patients in both groups after taking the medicine.Results:Before treatment,the general data(gender,age,onset time,duration of illness),NIHSS score,modified Rankin Scale,BI index and TCM syndromic score were comparable between the two groups(P>0.05),and were comparable.After 14 days of treatment,the NIHSS score,modified Rankin Scale,and TCM syndromes scores decreased in both groups;the BI index scores improved significantly;the treatment efficiency of patients in the observation group(89.60%)was higher than that of the control group(68.80%),P< 0.05;the treatment efficiency of TCM syndromes in the observation group(89.60%)was higher than that of the control group(72.92%),P < 0.05.The incidence of adverse reactions in the observation group(2.10%)was much lower than that in the control group(8.33%),P < 0.05.The improvement of all indexes in the observation group was significantly better than that in the control group,P < 0.05,and the difference was statistically significant.ConclusionThe treatment of acute stage of stroke(wind-phlegm blockage evidence)with Xingnao Zhitan Capsule and Xingnao Kaiqiao is clinically effective,with high safety,few side effects,good recovery of neurological functions,and improvement of patients’ symptoms and activities of daily living,which is worth popularizing in clinical application. |
