Clinical Study On Treatment Of Acute Ischemic Stroke With Jiawei Buyang Huanwu Decoction Combined With Xingnao Kaiqiao Acupuncture

Objective:To explore the clinical efficacy and safety of Jiawei Buyang Huanwu decoction combined with Xingnao Kaiqiao Acupuncture in treating acute ischemic stroke patients with Qi deficiency and blood stasis,in order to provide clinical basis for treatment.Methods: A total of 120 inpatients who met the criteria in the Hospital of Traditional Chinese Medicine from August 2017 to December 2018 were randomly divided into the TCM group(40 cases),the butylphthalide group(40 cases),and the conventional group.40 cases).The conventional group was treated with Western medicine routinely.The TCM group was supplemented with Jiawei Buyang Huanwu Decoction combined with Xingnao Kaiqiao acupuncture on the basis of Western medicine routine treatment.The butylphthalide group was treated with butylphthalide sodium chloride injection and Western medicine.The National Institute of Health Stroke Scale(NIHSS)score,modified Barthel(BI)index and TCM syndrome scores and related adverse reactions were measured before and after treatment.The clinical efficacy and safety of the two groups were compared.Results: 1.Neurologic deficit score(1)There was no significant difference in NIHSS score before treatment among the three groups(P=0.845>0.05).(2)There were significant differences in NIHSS scores after treatment among the three groups(P=0.001<0.01).There was no significant difference between TCM group and butylphthalein group after treatment(P=1.000>0.05),but there was significant difference between TCM group and conventional group after treatment(P=0.001<0.01),and there was significant difference between butylphthalein group and conventional group after treatment(P=0.007<0.01).(3)There were statistically significant differences in NIHSS scores before and after treatment in each group(TCM group: P<0.01;butylphthalein group: P<0.01;conventiona group: P<0.01).2.The scores of activity of daily living(1)There was no significant difference in BI score before treatment among the three groups(P=0.571>0.05).(2)There were significant differences in BI scores after treatment among the three groups(P=0.004<0.01).There was no significant difference between TCM group and butylphthalein group after treatment(P=1.000>0.05),but there was significant difference between TCM group and conventional group after treatment(P=0.030<0.05),and there was significant difference between butylphthalein group and conventional group after treatment(P=0.005<0.01).(3)There were statistically significant differences in BI scores before and after treatment in each group(TCM group: P<0.01;butylphthalein group: P<0.01;conventiona group: P<0.01).3.Clinical symptoms of TCM(1)There was no statistical significance(P=0.853>0.05)in the three groups of TCM clinical symptoms before and after the treatment.(2)There were significant differences among the three groups in clinical symptom scores after treatment(P=0.042<0.05).There was significant difference between TCM group and conventional group after treatment(P=0.012<0.05),there was no significant difference between TCM group and butylphthalein group after treatment(P=0.235>0.05),and there was no significant difference between butylphthalein group and conventional group after treatment(P=0.177>0.05).(3)The difference between the three groups of TCM clinical symptoms before and after the treatment was statistically significant(TCM group: P<0.01;butylphthalein group: P<0.01;conventiona group: P<0.01).4.Clinical efficacy of neurological function The clinical efficacy of neurological function in the TCM group was 90%;the butylphthalide group was 87.5%;the conventiona group was 60%.There were significant differences in the clinical efficacy of neurological function among the three groups(P=0.001<0.01).There was no significant difference between TCM group and butylphthalein group after treatment(P=1.000>0.05),but there was significant difference between TCM group and conventional group after treatment(P=0.002<0.01),and there was significant difference between butylphthalein group and conventional group after treatment(P=0.005<0.01).5.Clinical efficacy of TCM The effective rate of clinical efficacy of TCM in the acupuncture group was 92.5%;the effective rate of butylphthalide group was 77.5%;the effective rate of routine group was 60%.There were significant differences in the clinical efficacy of TCM among the three groups(P=0.003<0.01).There was no significant difference between TCM group and butylphthalein group after treatment(P=0.235>0.05),but there was significant difference between TCM group and conventional group after treatment(P=0.001<0.01),and there was no significant difference between butylphthalein group and conventional group after treatment(P=0.091<0.05).Conclusion: Jiawei Buyang Huanwu decoction combined with Xingnao Kaiqiao Acupuncture can improve the neurological function defect,activity of daily living and clinical symptoms of patients with acute ischemic stroke of Qi deficiency and blood stasis type,the clinical effect is significant.